Universal precautions

Comparative evaluation of feature selection methods for HRV-based survival modeling in HIV-positive ICU patients: a retrospective study.

Enthusiasm and hesitation: a structural topic modelling analysis of long-acting injectable PrEP perceptions among Dutch-speaking MSM.

BACKGROUND: Long-acting injectable PrEP (LA-PrEP) is a novel HIV prevention modality recently approved in Europe, offering an important addition to HIV prevention options. Understanding user perceptions early is critical for anticipating uptake, addressing barriers, and shaping implementation. This study aimed to identify the latent qualitative themes surrounding LA-PrEP among Dutch-speaking men-w...

Assessing plague risk across seven decades of environmental change in Inner Mongolia, China: An interpretable machine learning.

Plague, caused by Yersinia pestis, persists as a public health threat, particularly in natural foci such as China's Inner Mongolia Autonomous Region. ...

Using Machine Learning to Design Effective Antimicrobial Dosing Regimens.

Resistant bacterial infections remain a major clinical challenge, often necessitating combination therapy, namely use of two or more antibiotics with ...

Study on material basis and network mechanism of the Guizhi Fuling pills in the treatment of endometriosis and endometrial polyps.

To explore the material basis and network mechanism of the Guizhi Fuling pills in the treatment of endometriosis and endometrial polyps based on netwo...

Accelerating tuberculosis diagnosis in Mozambican prisons using digital chest X-rays with computer-aided detection: a longitudinal, comprehensive health intervention.

BACKGROUND: Mozambique has a high burden of tuberculosis (TB) and in 2021, an estimated 18,000 persons with TB nationwide were not diagnosed. Estimate...

Contrast-Enhanced VM-UNet for Thyroid Nodule Segmentation Based on Wavelet Features and Dual-Branch Edge Learning.

Accurate segmentation of thyroid nodules from ultrasound images is critical for clinical diagnosis and treatment, as manual analysis is labor-intensiv...

Annular Prior Prompt Learning for Medical Images Segmentation.

Excellent performance has been achieved on medical image segmentation. Still, existing algorithms perform relatively poorly for annular objects with h...

A metabolite-augmented FIB-4 machine learning panel achieves superior liver fibrosis staging in chronic liver disease.

Accurate, non-invasive liver fibrosis detection is essential for chronic liver disease management, particularly with rising metabolic dysfunction-asso...

Optimizing Machine Learning-Based Diagnosis of Neurosyphilis in HIV-Negative Patients: A Multicenter, Real-World Comparison of International Diagnostic Criteria.

AbstractNeurosyphilis continues to rise globally, yet diagnosis remains challenging, often requiring multidisciplinary expertise and multiple CSF assa...

Revisiting the NETs-CYBB-p38 MAPK axis in bronchiectasis: The underlying oxidative injury mechanism.

BACKGROUND: Bronchiectasis is a chronic neutrophilic respiratory disease frequently complicated by Pseudomonas aeruginosa (P. aeruginosa) infection. N...

Rational Design of Broad-Spectrum Non-Nucleoside Reverse Transcriptase Inhibitors via Pharmacophore-Oriented Generative Artificial Intelligence.

Guided by the pharmacophore-oriented molecular generation platform PhoreGen, we employed rilpivirine (RPV) as a lead compound to generate 300 structur...

Virtual cell/virtual cell like: The key to unlocking a new era of HIV/AIDS treatment ?

Virtual Cell (VC) technology, as an interdisciplinary frontier at the intersection of systems biology and computational biology, aims to precisely sim...

Clinical Care Practices Shape Microbiome-Associated Bloodstream Infection Risk in Geographically Distinct NICUs.

BACKGROUND: Bloodstream infections (BSI) remain a major cause of morbidity and mortality in preterm infants. Although BSI pathogens vary geographicall...

Harnessing machine learning with auditory tests and demographic factors to forecast children's reading abilities in children living with and without HIV.

Proteomic profiling and pathway analyses reveal molecular signatures and immune networks in pediatric sepsis.

BACKGROUND: Sepsis remains a leading cause of childhood mortality worldwide. Most deaths occur within the first few days of presentation, underscoring...

PTBD: a machine learning-based non-invasive diagnostic model for pulmonary tuberculosis using large-scale blood transcriptomes.

BACKGROUND: Accurate and rapid diagnosis is essential for controlling pulmonary tuberculosis (PTB) by enabling timely intervention and reducing diseas...

AI-MedCraft: A Strategy-Driven AI Platform for Multi-Objective Molecular Design.

Small-molecule drug discovery requires balancing potency, selectivity, solubility, safety, and synthetic feasibility, among other interdependent prope...

Global prevalence and distribution of bla-harboring Salmonella: A genome-wide association study of cephalosporin resistance mechanisms.

Given the increasing global concern over Salmonella resistance to cephalosporins, such resistance poses serious challenges to food safety and clinical...

CRISPR/Cas12a: A Comprehensive Review from Structural Foundations to Applications in Nucleic Acid Precision Detection.

CRISPR/Cas12a technology, characterized by its distinctive trans-cleavage activity, has evolved beyond its gene-editing function to emerge as a powerf...