Urology

Hypoferremic Response to Chronic Inflammation Is Controlled via the Hemojuvelin/Hepcidin/Ferroportin Axis and Does Not Involve Hepcidin-Independent Regulation of Fpn mRNA.

The iron regulatory hormone hepcidin contributes to the pathogenesis of anemia of inflammation (AI) by inhibiting the iron exporter ferroportin in target cells, causing hypoferremia. Under acute inflammation, hepcidin induction requires hemojuvelin (Hjv), a bone morphogenetic protein co-receptor, while Fpn mRNA is also suppressed in a hepcidin-independent manner. However, it is unclear whether, du...

Push Forward Clinical Management of Hematological Toxicity due to Lenalidomide Overexposure: Model-Informed Precision Dosing for Chinese Population With Renal Insufficiency.

Dose-dependent hematological toxicity of lenalidomide has been reported previously, and thus, there is a clinical need for dose individualization to manage toxicities. The objectives of this study were to explore optimal individualized dosing regimens for Chinese B-cell malignancies patients with varying degrees of renal function, and to push forward clinical management of hematological toxicity d...

Prostate cancer clinicopathological presentation in South-East Africa during the 2010 decade.

Prostate cancer (PCa) is the leading cause of cancer-associated death amongst men across Sub-Saharan Africa, with Southern and East Africa ranking 1st...

Optimizing Fragmentation while Minimizing Thermal Injury Risk with the Thulium Fiber Laser in Ureteral Stone Lithotripsy: An In Vitro Study.

To optimize thulium fiber laser (TFL) settings for effective stone fragmentation although minimizing thermal injury in confined ureteral spaces using...

Single-port laparoscopic cholecystectomy with indocyanine green: A propensity score study.

INTRODUCTION: This study aims to compare the clinical efficacy of single-incision laparoscopic cholecystectomy (SILC) with indocyanine green (ICG) flu...

Dual nanozyme sensor enables rapid at-home cancer surveillance.

Early detection of cancer is critical for improving patient survival rates, and current in vitro diagnostic methods show great potential, particularly...

Corrigendum to 'Application of AI-MR in the Planning of PCNL for Special Types of Complex Upper Urinary Stones: A Pilot Study' [Urology 196 (2025) 40-47].

PSMA MRI Guided Prostate SABR ARGOS-CLIMBER Phase I/II Trial: A Primary Endpoint Analysis.

PURPOSE: The XXXXX trial is a multi-institutional phase I/II study utilizing a combined PSMA PET/MRI approach to treat dominant intraprostatic lesions...

Inadequate imipenem dosing in patients with decreased kidney function: A clinical pharmacokinetic study.

OBJECTIVES: A number of population pharmacokinetic (popPK) models of imipenem in critically ill patients are available for dosing optimisation, but th...

Analysis of gray zone PSA and PSAD correlated with PIRADS v2.1 in the MRI-US fusion prostate biopsy era: a retrospective bi-centre study.

BACKGROUND: Multiple parameters including PSA, PSAD, and PIRADS v2.1 score, are being associated in an effort to increase the overall detection rate o...

Deep learning assisted identification of SCUBE2 and SLC16 A5 combination in RNA-sequencing data as a novel specific potential diagnostic biomarker in prostate cancer.

Despite the extensive use of biomarkers like PSA, AMACR, and PCA3, prostate cancer (PCa) is still a major clinical challenge, demanding the developmen...

Comparison of Machine Learning Algorithms and Bayesian Estimation in Predicting Tacrolimus Concentration in Tunisian Kidney Transplant Patients During the Early Post-Transplant Period.

BACKGROUND AND OBJECTIVE: Model-informed precision dosing (MIPD), based on a Bayesian approach and machine learning (ML) algorithms, is a suitable app...

Using N-Nitrosodiethanolamine (NDELA) and N-Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency-Based Acceptable Intakes for NDSRIs Lacking Robust Carcinogenicity Data.

Acceptable intake (AI) limits for nitrosamine drug substance related impurities (NDSRIs) that lack carcinogenicity data could be estimated from mutage...

AI-driven glomerular morphology quantification: a novel pipeline for assessing basement membrane thickness and podocyte foot process effacement in kidney diseases.

BACKGROUND AND OBJECTIVE: Measuring the thickness of the glomerular basement membrane (GBM) and assessing the percentage of podocyte foot process effa...

Systemic inflammation mediates the relationship between urinary cadmium and chronic cough risk: findings based on multiple statistical models.

Epidemiological research examining the relationship between urinary cadmium and the risk of chronic cough remains scarce. This study included 2965 par...

Mechanisms involved in pro-inflammatory responses to traffic-derived particulate matter (PM) in THP-1 macrophages compared to HBEC3-KT bronchial epithelial cells.

The pro-inflammatory responses in THP-1-derived macrophages and human bronchial epithelial cells (HBEC3-KT) were examined after exposure to size-fract...

The added value of artificial intelligence using Quantib Prostate for the detection of prostate cancer at multiparametric magnetic resonance imaging.

PURPOSE: Artificial intelligence (AI) has been proposed to assist radiologists in reporting multiparametric magnetic resonance imaging (mpMRI) of the ...

Enhancing Organ Allocation Efficiency: A Pilot Study Evaluating Artificial Intelligence-Assisted Assessment of Donor Kidney Pathology.

PURPOSE: The purpose of this study is to evaluate the effectiveness of an artificial intelligence (AI)-assisted review (AAR) system in improving diagn...

Machine learning-derived multivariate renal function trajectories in acute kidney injury in critically ill patients: a multicentre retrospective study.

BACKGROUND: Acute kidney injury (AKI) exhibits considerable heterogeneity. The objective of the current study was to identify AKI subphenotypes in int...

Comparative Analysis of Machine Learning Models for Predicting Hospital- and Community-Associated Urinary Tract Infections Using Demographic, Hospital, and Socioeconomic Predictors.

BACKGROUND: Urinary tract infections (UTI) are among the most common infections encountered in both community and healthcare settings. Differentiating...