Vaccines

Genomic evolution of SARS-CoV-2 delta variants pre- and post-omicron emergence using alignment-free machine learning models.

The SARS-CoV-2 Delta variant (B.1.617.2), initially classified as a variant of concern due to its enhanced transmissibility and vaccine-escape mutations, underwent further genomic changes following the emergence of the Omicron variant (B.1.1.529). This study investigates the genomic differences in Delta variant spike gene sequences collected before and after the emergence of Omicron. A total of 19...

mRNA-based cancer vaccines: A new frontier in personalized immunotherapy.

The advancement of mRNA technology has rejuvenated the cancer treatment immunotherapy field by providing a flexible and scalable platform to generate tumor-associated or patient-specific neoantigens, which induces strong cytotoxic and helper T-cell outcomes and also immunologically stimulates innate immunity in the body at the same time. In contrast to conventional vaccines, mRNA preparations are ...

Artificial intelligence-guided design of LNPs for in vivo targeted mRNA delivery via analysis of the spatial conformation of ionizable lipids.

Efficient mRNA delivery to specific tissues requires optimized ionizable lipids, yet the role of lipid spatial conformation in organ targeting and end...

Veteran oropharyngeal cancer outcomes in the modern era: a multi-institutional retrospective analysis.

OBJECTIVE: To define oncologic outcomes in Veterans in the modern era using a multi-institutional cohort designed to support development and validatio...

GeoPMB: An Interface-Aware Geometric Deep Learning Framework for Peptide-MHCI Binding Prediction with Evolutionary Insight.

The binding of peptides to class I major histocompatibility complex (MHCI) molecules is central to adaptive immunity, making the identification of imm...

MicroRNAs in penile cancer: challenges, opportunities, and translational perspectives.

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression, and dysregulated miRNA expression has been implicated in multiple cancer h...

Machine learning and the role of the vaginal and fecal microbiome in miscarriage: a matched case-control study.

Miscarriage occurs in approximately 15% of all pregnancies, and recent studies have suggested a potential role of the microbiome. A nested case-contro...

Colonoscopy surveillance in Lynch syndrome: what it prevents and what it does not.

Lynch syndrome (LS), synonymous with hereditary non-polyposis colorectal cancer (HNPCC), is caused by germline pathogenic variants in MLH1, MSH2, MSH6...

Predictive proteomics: Binary classification of Streptococcus pneumoniae vaccine types via MALDI-TOF MS and supervised learning algorithms.

INTRODUCTION: Laboratory surveillance of Streptococcus pneumoniae serotypes is crucial for the effective implementation of vaccines against invasive p...

Integrated reiterative pipeline for rapid epitope-based pan-alphavirus vaccines.

The vast diversity of the virosphere underscores the need for rapid, adaptable vaccine development infrastructures. Arthropod-borne zoonotic alphaviru...

Machine learning-based 4-domain framework for evaluating COVID-19 policy responses: a counterfactual analysis of 27 European OECD countries.

OBJECTIVES: European countries implemented highly diverse mitigation policies during the COVID-19 pandemic, ranging from strict nationwide lockdowns t...

Bridging immunization gaps in Sub-Saharan Africa: a narrative review of microplanning, geospatial, and machine learning approaches to reach zero-dose children and under-immunised children.

Immunization inequities persist across Sub-Saharan Africa, with significant numbers of zero-dose and under-immunised children contributing to preventa...

Sociodemographic Risk Factors for Incomplete Routine Childhood Immunizations Among Children Born During the COVID-19 Pandemic, Louisiana, March 1, 2020-July 1, 2021.

OBJECTIVE: Routine childhood vaccination rates declined nationwide among children born during 2020-2021 compared with prior birth cohorts. We identifi...

The adaptive large language models for vaccine prediction: A novel approach to vaccine demand prediction with engineered deviation prompts.

Accurate vaccine demand forecasting is crucial for minimizing wastage and ensuring efficient immunization programs. In this study, we introduce an Ada...

Overcoming gastrointestinal mucosal barriers: Mechanistic innovations and technical advances in mucosal targeting strategies for animal oral vaccines.

Infectious diseases caused by pathogenic microorganisms (such as Escherichia coli, Avian influenza virus (AIV), Rotavirus, etc.) that primarily invade...

Cross-Cultural Differences in Public Discourse on COVID-19 Vaccination in the United States and South Korea: Cross-Sectional Analysis Using Natural Language Processing.

BACKGROUND: The COVID-19 vaccine was introduced as a crucial tool to combat the pandemic. However, concerns about its effectiveness, side effects, and...

RNA therapeutics 2.0: Expanding the landscape from mRNA vaccines to splicing modulators and beyond.

RNA therapeutics have progressed into a disruptive drug class quickly, replacing a variety of primary experimental agents which included vaccines, ant...

Exploring the impact of reimbursement ratios on willingness to vaccinate: A mixed-effects modeling approach using panel data.

Vaccination remains one of the most cost-effective methods for disease prevention. However, utilization of self-paid vaccines, including EV71, varicel...

Host-focused immunity, metabolism, and diagnostic innovation for precision control of tuberculosis globally.

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains one of the deadliest infectious diseases worldwide. Despite advances in treatme...

Redefining Cytotechnologist Practice in Sweden: National Survey on Workload, Expanded Roles, and Future Competency Needs.

INTRODUCTION: Cytotechnologists have long been central to cervical cancer screening, although their education and job responsibilities differ markedly...