Vaccines

The Time for Cancer Vaccines Is Now: Advancing Toward Lasting Cancer Immunity.

A multi-phase, multi-method assessment of national COVID-19 vaccination performance with equity analysis.

Update on Non-Biological and RNA-Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules.

In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic infla...

Machine learning model predicts prognosis in SARS-CoV-2-infected autoimmune encephalitis patients.

OBJECTIVE: To assess the neurological prognosis of patients with autoimmune encephalitis (AE) after severe acute respiratory syndrome coronavirus 2 (S...

CRISPR-initiated exponential amplification on fluorescently-barcoded microspheres for deep learning-assisted multiplexed HPV detection.

Rapid, low-cost, and multiplexed nucleic acid testing is essential for human health but remains challenging. Although CRISPR-Cas systems offer high sp...

Impacts of delayed influenza vaccination on clinical outcomes in ICU-admitted patients with influenza: A retrospective cohort study.

BACKGROUND: Influenza vaccination is an effective measure for reducing the risk of severe influenza infection. However, the task of achieving adequate...

Integrated single-cell analyses of affinity-tested B cells enable the identification of a gene signature to predict antibody affinity.

Advancements in single-cell technologies and deep sequencing have expanded the B cell repertoire available for antibody discovery. However, selecting ...

Accelerating Siloxane-Based Ionizable Lipid Design for LNPs with Data-Efficient Kolmogorov-Arnold Networks.

Ionizable lipids are fundamental to the efficacy of lipid nanoparticles (LNPs) in pivotal areas including mRNA vaccines. Their development, however, i...

Predicting genetic evolution of viruses to identify suitable vaccines using artificial intelligence.

The evolution of the viruses is rapidly becoming a global challenge to the creation of vaccines since the new variants are often capable of escaping t...

Modeling Zero-Dose Children in Ethiopia: A Machine Learning Perspective on Model Performance and Predictor Variables.

BACKGROUND: Despite progress in childhood vaccination, many children in low- and middle-income countries, including Ethiopia, remain unvaccinated, pre...

Machine learning-driven identification of serotype-independent pneumococcal vaccine candidates using samples from human infection challenge studies.

Identifying conserved, immunogenic proteins that confer protection against Streptococcus pneumoniae (pneumococcus) colonization could enable developme...

Highly efficient and durable Th1-biased protective immunity from a novel mRNA vaccine against RSV via AI-assisted antigen screening.

Respiratory syncytial virus (RSV) is a leading cause of severe respiratory illness, imposing a significant burden on global health and society. Here, ...

Cervical cancer cell prediction and detection with high test accuracy based on a reliable automated system.

Cervical cancer ranks as the fourth most prevalent cancer among women worldwide. The increasing incidence and mortality rates are largely attributed t...

The use of artificial intelligence in decreasing vaccine skepticism and hesitancy.

PURPOSE OF REVIEW: Recent advances in artificial intelligence (AI) coincide with decreases in confidence in vaccines. This review examines studies tha...

A novel hypothetical protein (SAUSA300_1684) confers excellent protection against multi-drug-resistant Staphylococcus aureus infection in the murine model.

Staphylococcus aureus is a leading cause of nosocomial infections, including sepsis, bacteraemia, pneumonia, and endocarditis, and continues to pose a...

A Comparative Study of Machine Learning Models for Identification of Antiviral Peptides Using Various Encoded Features.

Viruses are a significant threat to human life, as demonstrated by the global COVID-19 pandemic and the Ebola outbreak. Diseases such as smallpox, AID...

Complex Interactions Between Stress, Nutrition, Gut Microbiota, and Infectious Diseases and Their Impact on Health in Global Conflicts: A Narrative Review.

Following the global recovery from the COVID-19 pandemic, wars and conflicts have escalated to levels unseen since the Cold War. It is well known that...

Programmable lipid nanoparticles for RNA therapeutics: Design principles and clinical translation.

RNA therapeutics have come of age as clinically validated modalities including mRNA, siRNA, antisense oligonucleotides (ASOs), and in vivo genome edit...

Advances in melanoma immunotherapy: harnessing vaccination as a potential novel immunotherapeutic strategy.

Melanoma, an aggressive form of skin cancer, demands innovative immunotherapeutic strategies to improve patient outcomes. This review explores recent ...

Artificial intelligence for colposcopic and cytological image analysis in early cervical cancer detection.

Artificial intelligence (AI) is reshaping cervical cancer screening by automating interpretation of cytology, colposcopic, and related imaging to impr...