Infectious Disease

Vaccines

Latest AI and machine learning research in vaccines for healthcare professionals.

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Predicting cervical intraepithelial neoplasia and determining the follow-up period in high-risk human papillomavirus patients.

PURPOSE: Despite strong efforts to promote human papillomavirus (HPV) vaccine and cervical cancer screening, cervical cancer remains a threat to women's reproductive health. Some high-risk HPV types play a crucial role in the progression of cervical cancer and precancerous lesions. Therefore, HPV screening has become an important means to prevent, diagnose, and triage cervical cancer. This study a...

Jan 17 2024 38298438

Generative artificial intelligence can have a role in combating vaccine hesitancy.

Artificial intelligence has potential to counter vaccine hesitancy while building trust in vaccines, but it must be deployed ethically and responsibly, argue

Jan 16 2024 38228351
Comparison of hepatitis B and SARS-CoV2 vaccination rates in people who attended Drugs and Addiction Centres.

BACKGROUND AND AIMS: Persons with substance use disorder are at increased risk for hepatitis B virus (HBV) infection. Although most of them are attach...

Jan 16 2024 38292385
Classification of MLH1 Missense VUS Using Protein Structure-Based Deep Learning-Ramachandran Plot-Molecular Dynamics Simulations Method.

Pathogenic variation in DNA mismatch repair (MMR) gene is associated with Lynch syndrome (LS), an autosomal dominant hereditary cancer. Of the 3798 ...

Jan 10 2024 38255924
CanVaxKB: a web-based cancer vaccine knowledgebase.

Cancer vaccines have been increasingly studied and developed to prevent or treat various types of cancers. To systematically survey and analyze differ...

Jan 9 2024 38204924
A facile approach to preparing personalized cancer vaccines using iron-based metal organic framework.

BACKGROUND: Considering the diversity of tumors, it is of great significance to develop a simple, effective, and low-cost method to prepare personaliz...

Jan 8 2024 38259474
Direct Detection of 4-Dimensions of SARS-CoV-2: Infection (vRNA), Infectivity (Antigen), Binding Antibody, and Functional Neutralizing Antibody in Saliva.

We developed a 4-parameter clinical assay using Electric Field Induced Release and Measurement (EFIRM) technology to simultaneously assess SARS-CoV-2 ...

Dec 28 2023 38234820
Microsatellite Instability, Mismatch Repair, and Tumor Mutation Burden in Lung Cancer.

Since US Food and Drug Administration approval of programmed death ligand 1 (PD-L1) as the first companion diagnostic for immune checkpoint inhibitors...

Dec 20 2023 38692812
Structure-based approaches against COVID-19.

The coronavirus disease 2019 (COVID-19) pandemic has had a major impact on human life. This review highlights the versatile roles of both classical an...

Dec 20 2023 38305483
Humoral Immune Responses after an Omicron-Adapted Booster BNT162b2 Vaccination in Patients with Lymphoid Malignancies.

To accommodate waning COVID-19 vaccine immunity to emerging SARS-CoV-2 variants, variant-adapted mRNA vaccines have been introduced. Here, we examine ...

Dec 20 2023 38275946
Hybrid grey assisted whale optimization based machine learning for the COVID-19 prediction.

Recently, COVID-19 (coronavirus) has been a huge influence on the socio and economic field. COVID-19 cases are seriously increasing day-day and also d...

Dec 19 2023 38112339
Predicting COVID-19 pandemic waves including vaccination data with deep learning.

INTRODUCTION: During the recent COVID-19 pandemics, many models were developed to predict the number of new infections. After almost a year, models ha...

Dec 15 2023 38162619
Characterizing adjuvants' effects at murine immunoglobulin repertoire level.

Generating large-scale, high-fidelity sequencing data is challenging and, furthermore, not much has been done to characterize adjuvants' effects at th...

Dec 14 2023 38269092
Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial.

BACKGROUND: Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a...

Dec 12 2023 38267107
Optimizing Signal Management in a Vaccine Adverse Event Reporting System: A Proof-of-Concept with COVID-19 Vaccines Using Signs, Symptoms, and Natural Language Processing.

INTRODUCTION: The Vaccine Adverse Event Reporting System (VAERS) has already been challenged by an extreme increase in the number of individual case s...

Dec 7 2023 38062261
Deep learning framework for epidemiological forecasting: A study on COVID-19 cases and deaths in the Amazon state of ParĂ¡, Brazil.

Modeling time series has been a particularly challenging aspect due to the need for constant adjustments in a rapidly changing environment, data uncer...

Nov 17 2023 37976312
Experimental validation of immunogenic SARS-CoV-2 T cell epitopes identified by artificial intelligence.

During the COVID-19 pandemic we utilized an AI-driven T cell epitope prediction tool, the NEC Immune Profiler (NIP) to scrutinize and predict regions ...

Nov 17 2023 38045681
COVID-19 Vaccination in Liver Cirrhosis: Safety and Immune and Clinical Responses.

INTRODUCTION: Three years after the beginning of the SARS-CoV-2 pandemic, the safety and efficacy of COVID-19 vaccination in liver cirrhosis (LC) pati...

Nov 15 2023 39360169
Transfer of maternal immunity using a polyvalent vaccine and offspring protection in Nile tilapia, .

BACKGROUND: Vaccination is an effective and alternative means of disease prevention, however, it cannot be conducted on the offspring of fish. For thi...

Nov 10 2023 37767359
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