Vaccines

Comparative study of lipid nanoparticle-based mRNA vaccine bioprocess with machine learning and combinatorial artificial neural network-design of experiment approach.

To develop a combinatorial artificial-neural-network design-of-experiment (ANN-DOE) model, the effect of ionizable lipid, an ionizable lipid-to-cholesterol ratio, N/P ratio, flow rate ratio (FRR), and total flow rate (TFR) on the outcome responses of mRNA-LNP vaccine were evaluated using a definitive screening design (DSD) and machine learning (ML) algorithms. Particle size (PS), PDI, zeta potenti...

DeepBCE: Evaluation of deep learning models for identification of immunogenic B-cell epitopes.

B-Cell epitopes (BCEs) can identify and bind with receptor proteins (antigens) to initiate an immune response against pathogens. Understanding antigen-antibody binding interactions has many applications in biotechnology and biomedicine, including designing antibodies, therapeutics, and vaccines. Lab-based experimental identification of these proteins is time-consuming and challenging. Computationa...

Screening for extranodal extension in HPV-associated oropharyngeal carcinoma: evaluation of a CT-based deep learning algorithm in patient data from a multicentre, randomised de-escalation trial.

BACKGROUND: Pretreatment identification of pathological extranodal extension (ENE) would guide therapy de-escalation strategies for in human papilloma...

An investigation into epidemiological situations of COVID-19 with fuzzy K-means and K-prototype clustering methods.

The ten countries with the highest population during the pandemic were analyzed for clustering based on the quantitative numbers of COVID-19 and polic...

Lexicon-based sentiment analysis to detect opinions and attitude towards COVID-19 vaccines on Twitter in Italy.

The paper proposes a methodology based on Natural Language Processing (NLP) and Sentiment Analysis (SA) to get insights into sentiments and opinions t...

Leveraging deep learning to improve vaccine design.

Deep learning has led to incredible breakthroughs in areas of research, from self-driving vehicles to solutions, to formal mathematical proofs. In the...

CT-based deep learning model for the prediction of DNA mismatch repair deficient colorectal cancer: a diagnostic study.

BACKGROUND: Stratification of DNA mismatch repair (MMR) status in patients with colorectal cancer (CRC) enables individual clinical treatment decision...

Racial Health Disparities and Black Heterogeneity in COVID-19: A Case Study of Miami Gardens.

The COVID-19 pandemic is a critical public health concern that has disproportionately affected the Black community in the United States. The purpose o...

Molecular modeling of C1-inhibitor as SARS-CoV-2 target identified from the immune signatures of multiple tissues: An integrated bioinformatics study.

The expeditious transmission of the severe acute respiratory coronavirus 2 (SARS-CoV-2), a strain of COVID-19, crumbled the global economic strength a...

Predicting Antigenic Distance from Genetic Data for PRRSV-Type 1: Applications of Machine Learning.

The control of porcine reproductive and respiratory syndrome (PRRS) remains a significant challenge due to the genetic and antigenic variability of th...

Integrative transcriptome analysis of SARS-CoV-2 human-infected cells combined with deep learning algorithms identifies two potential cellular targets for the treatment of coronavirus disease.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) quickly spread worldwide, leading coronavirus disease 2019 (COVID-19) to hit pandemic lev...

DeepClassPathway: Molecular pathway aware classification using explainable deep learning.

OBJECTIVE: HPV-associated head and neck cancer is correlated with favorable prognosis; however, its underlying biology is not fully understood. We pro...

Deep learning techniques for detecting and recognizing face masks: A survey.

The year 2020 brought many changes to the lives of people all over the world with the outbreak of COVID-19; we saw lockdowns for months and deaths of ...

Comments on "Identifying psychological antecedents and predictors of vaccine hesitancy through machine learning: A cross sectional study among chronic disease patients of deprived urban neighbourhood, India".

Dear Editor, we read the publication by Rustagi et al. "Identifying psychological antecedents and predictors of vaccine hesitancy through machine lear...

A novel hybrid approach for feature selection enhancement: COVID-19 case study.

Feature selection is a promising Artificial Intelligence technique for screening, analysing, predicting, and tracking current COVID-19 patients and li...

Identification of missing hierarchical relations in the vaccine ontology using acquired term pairs.

BACKGROUND: The Vaccine Ontology (VO) is a biomedical ontology that standardizes vaccine annotation. Errors in VO will affect a multitude of applicati...

Analysis on COVID-19 Infection Spread Rate during Relief Schemes Using Graph Theory and Deep Learning.

The novel coronavirus 2019 (COVID-19) disease is a pandemic which affects thousands of people throughout the world. It has rapidly spread throughout I...

Computational Scientific Discovery in Psychology.

Scientific discovery is a driving force for progress involving creative problem-solving processes to further our understanding of the world. The proce...

Novel Coronavirus and Common Pneumonia Detection from CT Scans Using Deep Learning-Based Extracted Features.

COVID-19 which was announced as a pandemic on 11 March 2020, is still infecting millions to date as the vaccines that have been developed do not preve...

Mortality Prediction Analysis among COVID-19 Inpatients Using Clinical Variables and Deep Learning Chest Radiography Imaging Features.

The emergence of the COVID-19 pandemic over a relatively brief interval illustrates the need for rapid data-driven approaches to facilitate clinical d...