Vaccines

Randomized clinical trial of a single versus a double dose of 13-valent pneumococcal conjugate vaccine in adults 55 through 74 years of age previously vaccinated with 23-valent pneumococcal polysaccharide vaccine.

INTRODUCTION: In older adults, prior administration of 23-valent pneumococcal polysaccharide vaccine (PPSV23) blunts the opsonophagocytic antibody (OPA) response to subsequent administration of 13-valent pneumococcal conjugate vaccine (PCV13). To determine whether a higher dose of PCV13 could mitigate this effect in adults 55 through 74 years of age, we compared OPA responses to a double dose of P...

Immunologic non-inferiority and safety of the investigational pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) 4-dose vial presentation compared to the licensed PHiD-CV 1-dose vial presentation in infants: A phase III randomized study.

BACKGROUND: To support vaccination programs in developing countries, a 4-dose vial presentation of pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) was developed. This study assessed immunologic non-inferiority and safety of the investigational PHiD-CV 4-dose versus licensed 1-dose vial presentation in infants.

Lung abscess caused by serotype 6B.

Lung abscess has been considered to be a rare complication of pneumococcal infection, and most cases are reported to be serotype 3. A 67-year-old man...

Purification of influenza virus-like particles using sulfated cellulose membrane adsorbers.

BACKGROUND: Vaccines based on virus-like particles (VLPs) are an alternative to inactivated viral vaccines that combine good safety profiles with stro...

Critical dynamics in population vaccinating behavior.

Vaccine refusal can lead to renewed outbreaks of previously eliminated diseases and even delay global eradication. Vaccinating decisions exemplify a c...

Lateral flow immunoassay and enzyme linked immunosorbent assay as effective immunomethods for the detection of synthetic cannabinoid JWH-200 based on the newly synthesized hapten.

In recent years, the use of synthetic cannabinoids (SCs) as drugs of abuse has greatly increased. SCs are associated with a risk of severe poisoning o...

Artificial lateral line based local sensing between two adjacent robotic fish.

The lateral line system (LLS) is a mechanoreceptive organ system with which fish and aquatic amphibians can effectively sense the surrounding flow fie...

An ultrasensitive electrochemical immunosensor for Cry1Ab based on phage displayed peptides.

The rapid and widespread adoption of Bacillus thuringiensis (Bt) proteins in genetically modified (GM) crops has raised concerns about the impact of G...

Self-enhanced PEI-Ru(II) complex with polyamino acid as booster to construct ultrasensitive electrochemiluminescence immunosensor for carcinoembryonic antigen detection.

In this work, the luminophor tris (4,4'-dicarboxylicacid-2,2'-bipyridyl) ruthenium (II) dichloride (Ru(dcbpy)) was linked to coreactant polyethylenimi...

A fuzzy MICMAC analysis for improving supply chain performance of basic vaccines in developing countries.

INTRODUCTION: In recent years, demand to improve child immunization coverage globally, and the development of the latest vaccines and technology has m...

Ab-initio conformational epitope structure prediction using genetic algorithm and SVM for vaccine design.

BACKGROUND AND OBJECTIVE: T-cell epitope structure identification is a significant challenging immunoinformatic problem within epitope-based vaccine d...

A robotic magnetic nanoparticle solid phase extraction system coupled to flow-batch analyzer and GFAAS for determination of trace cadmium in edible oils without external pretreatment.

A lab-made magnetic-mechanical robotic (MMR) system coupled to a flow-batch analyzer (FBA) for magnetic nanoparticles solid phase extraction (MSPE) is...

Predicting Ascospore Release of Monilinia vaccinii-corymbosi of Blueberry with Machine Learning.

Mummy berry, caused by Monilinia vaccinii-corymbosi, causes economic losses of highbush blueberry in the U.S. Pacific Northwest (PNW). Apothecia devel...

Post-boosting of classification boundary for imbalanced data using geometric mean.

In this paper, a novel imbalance learning method for binary classes is proposed, named as Post-Boosting of classification boundary for Imbalanced data...

A comparison of machine learning and Bayesian modelling for molecular serotyping.

BACKGROUND: Streptococcus pneumoniae is a human pathogen that is a major cause of infant mortality. Identifying the pneumococcal serotype is an import...

Identification of immune correlates of protection in Shigella infection by application of machine learning.

BACKGROUND: Immunologic correlates of protection are important in vaccine development because they give insight into mechanisms of protection, assist ...

TEPAPA: a novel in silico feature learning pipeline for mining prognostic and associative factors from text-based electronic medical records.

Vast amounts of clinically relevant text-based variables lie undiscovered and unexploited in electronic medical records (EMR). To exploit this untappe...

Lightweight predicate extraction for patient-level cancer information and ontology development.

BACKGROUND: Knowledge engineering for ontological knowledgebases is resource and time intensive. To alleviate these issues, especially for novices, au...

Leveraging machine learning-based approaches to assess human papillomavirus vaccination sentiment trends with Twitter data.

BACKGROUND: As one of the serious public health issues, vaccination refusal has been attracting more and more attention, especially for newly approved...

Ontology-based literature mining of E. coli vaccine-associated gene interaction networks.

BACKGROUND: Pathogenic Escherichia coli infections cause various diseases in humans and many animal species. However, with extensive E. coli vaccine r...