Vaccines

Partisan differences in childhood measles vaccination and general refusals: a retrospective cohort study of electronic health records in the United States, 1988-2024.

BACKGROUND: Vaccination remains one of the most effective public health tools globally. Yet recent years have seen increasing political polarization around vaccination, particularly in the United States, as well as measles outbreaks among unvaccinated children. Using individual-level data, we characterize the national evolution of parental political polarization in childhood vaccination refusal, t...

The dynamics of hepatitis B transmission with treatment and vaccination: A case study in the Ili Region of Xinjiang, China, by a physics-informed neural networks approach.

Hepatitis B virus (HBV) infection remains a leading cause of cirrhosis and hepatocellular carcinoma worldwide, and long-term control relies on sustained immunization and effective reduction of transmission. In high-burden settings, vaccination programs have expanded substantially, but there still exist differences in the immune response effect after vaccination and the phenomenon of post-vaccinati...

Concepts of RNA virus evolution for the design of better antiviral countermeasures.

This century, global human health has been marked by a seemingly increasing list of outbreaks and epidemics caused by RNA viruses - masters of rapid e...

On the Prediction of pDNA Productivity Across Diverse Bioprocesses Using Ensemble Hybrid Models.

The global demand for plasmid DNA (pDNA) is rapidly increasing due to its key role in the manufacture of mRNA vaccines and advanced therapy medicinal ...

Multi-omics precision diagnosis of brucellosis: Advances in biomarker discovery and clinical application.

Brucellosis, a neglected zoonosis caused by intracellular Brucella bacteria, remains a formidable global public health challenge, especially in develo...

RNA-based cancer immunotherapy: Harnessing the power of RNA nanoparticles for melanoma treatment.

RNA-based cancer immunotherapy has emerged as a next-generation strategy in oncology, harnessing the versatile properties of RNA molecules to activate...

Emerging Therapeutic Paradigms in Tuberculosis: Nanocarriers, Host-Directed Strategies, and Translational Pharmacology.

TB remains a significant global health burden due to protracted therapeutic courses, poor patient compliance, and toxicities associated with drug trea...

An integrated AI-driven vaccine design process: a systematic review of workflows from generative design to translational prediction.

Traditional vaccine development faced significant hurdles, including lengthy timelines and high costs, which hindered rapid responses to pathogens. Al...

A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction.

In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product qu...

A comparison of two- and three-dose MVA-BN mpox vaccination series on anti-monkeypox virus immunity.

The 2022 global outbreak of clade IIb mpox represented a turning point in public health's handling of poxviruses. The primary vaccine available for th...

Prediction of SARS-CoV-2 exposure through T cell activation profiles.

In the ongoing effort to study the SARS-CoV-2 virus and COVID-19 disease, assessment of the T cell immune response has guided vaccine and therapeutic ...

Design and in silico evaluation of an mRNA vaccine against HTLV-1 using AI-driven reverse vaccinology approaches.

Human T-lymphotropic virus type 1 (HTLV-1) is the first discovered human oncogenic retrovirus that can cause adult T-cell leukemia/lymphoma, HTLV-1-as...

Machine learning-enabled smartphone CRISPR-Cas12a lateral flow platform for sensitive detection of circulating HPV DNA.

Persistent infection with high-risk human papillomavirus (HPV) is a major cause of cervical cancer, and improved point-of-care (POC) detection is crit...

Integrating QSAR-Machine Learning, Biochemical Assays, and Molecular Dynamics for the Discovery of JAK2 Inhibitors in Cervical Cancer.

Cervical cancer remains a major global health challenge, where dysregulated JAK2 signaling constitutes a key molecular driver. Nevertheless, selective...

Controlled human malaria infection in adults identify combinations of merozoite antigens associated with clinical immunity.

Two vaccines are currently licensed against Plasmodium falciparum malaria but offer only partial protection that wanes, necessitating repeated dosing ...

Risk and Protective Factors Associated With HIV-Related Mortality in Children Receiving Antiretroviral Therapy: A Model-Based Meta-Regression.

IMPORTANCE: Mortality among children and young adolescents receiving antiretroviral therapy (ART) remains substantially higher in resource-limited set...

A Triage Model for HR-HPV Positive Women Based on Methylation of Human and HPV Genes.

The aim of this study is to develop a machine learning triage model for HR-HPV positive women based on methylation patterns of human and HPV genes to ...

Clinical Significance of Biomarkers in Oropharyngeal Squamous Cell Carcinoma: Recurrence Prediction and Treatment Response.

BACKGROUND: Oropharyngeal squamous cell carcinoma (OPSCC) accounts for a substantial proportion of head and neck cancers, with a rising incidence larg...

HyperHealth: a pilot study on AI-driven COVID-19 detection using hyperspectral fingertip images.

Despite the reduced impact of COVID-19 due to widespread vaccination and improved treatments, a critical need remains for accessible, scalable, and ra...

A cross-sectional protocol for experimental tongue high-density surface electromyography to detect and classify radiation-associated hypoglossal neuropathy.

BACKGROUND: Hypoglossal neuropathy is the most common lower cranial neuropathy detected as a delayed sequelae of Human Papillomavirus (HPV) -driven or...