Vaccines

Therapeutic targeting of Respiratory Syncytial Virus: Current pharmacological options and future directions in antiviral development.

Respiratory syncytial virus (RSV) remains a major cause of severe acute respiratory infections across the life course, particularly in infants, older adults, and immunocompromised individuals. For decades, clinical management relied almost exclusively on supportive care, while ribavirin, the only licensed antiviral, offered limited therapeutic benefit. The recent introduction of prefusion F (pre-F...

Adjuvant databases and knowledge bases for data-driven research: a computational biology perspective.

In adjuvant research, which has long relied on experience and trial and error, advancements in technologies in broad areas, including artificial intelligence (AI)/machine learning, enabling data-driven research, have supported the introduction of more evidence-based, efficient approaches. Data-driven research, including systems biology in vaccinology ('systems vaccinology'), requires not only anal...

Non-invasive CT-based Deep Learning for Human Papillomavirus Status Prediction in Oropharyngeal Cancer.

RATIONALE AND OBJECTIVES: Human papillomavirus (HPV) status is a critical biomarker for treatment planning and patient management in oropharyngeal can...

Atomic clarity: how structural biology is shaping blood-stage malaria vaccines.

Developing an effective malaria vaccine is challenging because Plasmodium parasites use complex strategies to invade host cells. The blood stage, wher...

Dissecting serum polyclonal antibody escape to SARS-CoV-2 variants by deep mutational learning.

Deep mutational scanning (DMS) has been extensively used to investigate how single-position mutations in the receptor-binding domain (RBD) affect bind...

In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer.

Antibodies are central mediators of the adaptive immune response, and they are powerful research tools and therapeutics. Antibody discovery requires s...

Modelling the epidemic dynamics of HPV among women in China and optimization of ongoing cervical cancer elimination strategies.

BACKGROUND: The infection of high-risk human papillomavirus (hr-HPV) and related cervical cancer have greatly threatened women's health. However, the ...

A deep dive into ferritin nanoparticle advancements: experimental and computational perspectives.

Ferritin, a natural iron-storage protein, has emerged as a versatile platform in nanotechnology and biomedicine due to its biocompatible 12 nm nanocag...

Decoding viral evolution through integrative bioinformatics: From genomes to global health.

Bioinformatics has transformed modern virology by linking genomic variation to epidemiology, protein structure, and public health action. This review ...

Divergent macrophage-regulated T cell states determine response to Bacillus Calmette-Guérin vaccine in high-risk bladder cancer.

BACKGROUNDPrimary therapy for high-risk bladder cancer (BCa) is repeated instillations of the tuberculosis vaccine Bacillus Calmette-Guérin (BCG). Alt...

Machine learning and meningitis prediction in pediatric invasive pneumococcal disease: a retrospective single-center study.

Can Algorithms Efficiently Identify Interpretable and Persuasive Message Features? An Agnostic Causal Machine Learning Approach.

Argument strength and message persuasiveness are key constructs in message effects research. Yet, researchers still lack a systematic and efficient ap...

Explainable artificial intelligence-enabled intertwined logistics analytics with application in poultry vaccine distribution in the Northwest of Iran.

Intertwining supply chains integrates the corresponding networks across several intersection points, such as suppliers, manufacturers, and transporter...

Development and validation of the Oxford Attitudes to Artificial Intelligence in Medicine Scale.

OBJECTIVE: Public willingness to accept medical artificial intelligence (AI) tools affect the potential real-world impact of these evolving technologi...

The long and winding road: the resilience of cervical cytology as a long-standing laboratory tool to aid the diagnosis of HPV-induced lesions.

BACKGROUND: Despite molecular advancements, cervical cytology remains a resilient and fundamental laboratory tool in the prevention of cervical cancer...

mRNASyner: An Integrative Framework for Full-Length mRNA Sequence Optimization via Multimodule Synergistic Design.

Messenger RNA (mRNA) technology holds great promise in biomedicine; however, its therapeutic efficacy relies heavily on translation efficiency and the...

Generative artificial intelligence-driven chatbots and medical misinformation: an accuracy, referencing and readability audit.

OBJECTIVES: Artificial intelligence (AI)-driven chatbots have been rapidly adopted across research, education, business, marketing and medicine. Most ...

Integrated computational screening of FDA-approved anticancer drugs as novel HPV-16 E6 inhibitors in cervical cancer.

Personalized neoantigen cancer vaccines: Why clinical benefit remains inconsistent.

Personalized cancer vaccines have re-emerged as a promising strategy in precision immunotherapy, driven by advances in tumor sequencing, neoantigen id...

Smart hydrogels for overcoming cancer multidrug resistance.

Multidrug resistance (MDR) remains the principal impediment to curative oncology, driven by complex interplays between cancer cells and the tumor micr...