Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 18, 2024
Therapeutic proteins, the fastest growing class of pharmaceuticals, are subject to rapid proteolytic degradation in vivo, rendering them inactive. Sophisticated drug delivery systems that maintain protein stability, prolong therapeutic effects, and r...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 16, 2024
This study introduces an artificial neural network (ANN) for image classification task, inspired by the aversive olfactory learning neural circuit in Caenorhabditis elegans (C. elegans). Although artificial neural networks (ANNs) have demonstrated re...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 12, 2024
Endometriosis affects over 190 million women globally, and effective therapies are urgently needed to address the burden of endometriosis on women's health. Using an artificial intelligence (AI)-driven target discovery platform, two unreported therap...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 12, 2024
Proteins play an essential role in various biological and engineering processes. Large protein language models (PLMs) present excellent potential to reshape protein research by accelerating the determination of protein functions and the design of pro...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 12, 2024
Aortic stenosis (AS) is the most common valvular heart disease in developed countries. High-fidelity preclinical models can improve AS management by enabling therapeutic innovation, early diagnosis, and tailored treatment planning. However, their use...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 4, 2024
Flexible strain monitoring of hand and joint muscle movement is recognized as an effective method for the diagnosis and rehabilitation of neurological diseases such as stroke and Parkinson's disease. However, balancing high sensitivity and large stra...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Nov 28, 2024
Recent advances in spatial transcriptomics have enabled simultaneous preservation of high-throughput gene expression profiles and the spatial context, enabling high-resolution exploration of distinct regional characterization in tissue. To effectivel...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Nov 22, 2024
Bacterial infection is a crucial factor resulting in public health issues worldwide, often triggering epidemics and even fatalities. The accurate, rapid, and convenient detection of viable bacteria is an effective method for reducing infections and i...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Nov 22, 2024
As technology advances, human-machine interaction (HMI) demands more intuitive and natural methods. To meet this demand, smart gloves, capable of capturing intricate hand movements, are emerging as vital HMI tools. Moreover, triboelectric-based senso...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Nov 19, 2024
Currently, the diagnosis of malocclusion is a highly demanding process involving complicated examinations of the dental occlusion, which increases the demand for innovative tools for occlusal data monitoring. Nevertheless, continuous wireless monitor...