Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sep 16, 2024
Two-photon high-speed fluorescence calcium imaging stands as a mainstream technique in neuroscience for capturing neural activities with high spatiotemporal resolution. However, challenges arise from the inherent tradeoff between acquisition speed an...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sep 12, 2024
Streptomyces produces diverse secondary metabolites of biopharmaceutical importance, yet the rate of biosynthesis of these metabolites is often hampered by complex transcriptional regulation. Therefore, a fundamental understanding of transcriptional ...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sep 12, 2024
Soft robots spark a revolution in human-machine interaction. However, developing high-performance soft actuators remains challenging due to trade-offs among output force, driving distance, control precision, safety, and compliance. Here, addressing t...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sep 11, 2024
Multimodal machine learning, as a prospective advancement in artificial intelligence, endeavors to emulate the brain's multimodal learning abilities with the objective to enhance interactions with humans. However, this approach requires simultaneous ...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sep 9, 2024
Humans recognize and manipulate objects relying on the multidimensional force features captured by the tactile sense of skin during the manipulation. Since the current sensors integrated in robots cannot support the robots to sense the multiple inter...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sep 6, 2024
Uncovering fine-grained phenotypes of live cell dynamics is pivotal for a comprehensive understanding of the heterogeneity in healthy and diseased biological processes. However, this endeavor poses significant technical challenges for unsupervised ma...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sep 3, 2024
Microbes are extensively present among various cancer tissues and play critical roles in carcinogenesis and treatment responses. However, the underlying relationships between intratumoral microbes and tumors remain poorly understood. Here, a MIcrobia...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Aug 29, 2024
Accurate prediction of protein-ligand binding affinities is an essential challenge in structure-based drug design. Despite recent advances in data-driven methods for affinity prediction, their accuracy is still limited, partially because they only ta...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Aug 29, 2024
The molecular representation model is a neural network that converts molecular representations (SMILES, Graph) into feature vectors, and is an essential module applied across a wide range of artificial intelligence-driven drug discovery scenarios. Ho...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Aug 19, 2024
The 3' untranslated regions (3'UTRs) of messenger RNAs contain many important cis-regulatory elements that are under functional and evolutionary constraints. It is hypothesized that these constraints are similar to grammars and syntaxes in human lang...