AI Medical Compendium Journal:
European journal of drug metabolism and pharmacokinetics

Showing 1 to 7 of 7 articles

Comparison of Machine Learning Algorithms and Bayesian Estimation in Predicting Tacrolimus Concentration in Tunisian Kidney Transplant Patients During the Early Post-Transplant Period.

European journal of drug metabolism and pharmacokinetics May 8, 2025
BACKGROUND AND OBJECTIVE: Model-informed precision dosing (MIPD), based on a Bayesian approach and machine learning (ML) algorithms, is a suitable approach to personalize dosage recommendations and to improve the concentration target attainment for e...
Male Middle Aged Adult Cross-Sectional Studies Drug Monitoring Tacrolimus Tunisia Immunosuppressive Agents Bayes Theorem Humans Machine Learning Kidney Transplantation Female Algorithms
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Host Biomarkers and Antibiotic Tissue Penetration in Sepsis: Insights from Moxifloxacin.

European journal of drug metabolism and pharmacokinetics Apr 23, 2025
BACKGROUND AND OBJECTIVE: Sepsis-induced pathophysiological changes may lead to pharmacokinetic variability which alters antibiotic concentrations at the host infection site. This poses a challenge in clinical practice, as sufficient antibiotic conce...
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Predicting Pharmacokinetics of Drugs Using Artificial Intelligence Tools: A Systematic Review.

European journal of drug metabolism and pharmacokinetics Mar 8, 2024
BACKGROUND AND OBJECTIVE: Pharmacokinetic studies encompass the examination of the absorption, distribution, metabolism, and excretion of bioactive compounds. The pharmacokinetics of drugs exert a substantial influence on their efficacy and safety. C...
Humans Artificial Intelligence Animals Models, Biological Area Under Curve Pharmacokinetics Pharmaceutical Preparations
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Neural Network Models for Predicting Solubility and Metabolism Class of Drugs in the Biopharmaceutics Drug Disposition Classification System (BDDCS).

European journal of drug metabolism and pharmacokinetics Oct 21, 2023
BACKGROUND AND OBJECTIVE: The biopharmaceutics drug disposition classification system (BDDCS) categorizes drugs into four classes on the basis of their solubility and metabolism. This framework allows for the study of the pharmacokinetics of transpor...
Pharmaceutical Preparations Drug Interactions Neural Networks, Computer Solubility Biopharmaceutics
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Development of a 2D-QSAR Model for Tissue-to-Plasma Partition Coefficient Value with High Accuracy Using Machine Learning Method, Minimum Required Experimental Values, and Physicochemical Descriptors.

European journal of drug metabolism and pharmacokinetics Jun 2, 2023
BACKGROUND: The demand for physiologically based pharmacokinetic (PBPK) model is increasing currently. New drug application (NDA) of many compounds is submitted with PBPK models for efficient drug development. Tissue-to-plasma partition coefficient (...
Plasma Machine Learning Random Forest Quantitative Structure-Activity Relationship Drug Development
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Pharmacokinetics of Eltrombopag in Healthy Chinese Subjects and Effect of Sex and Genetic Polymorphism on its Pharmacokinetic and Pharmacodynamic Variability.

European journal of drug metabolism and pharmacokinetics Mar 29, 2021
BACKGROUND AND OBJECTIVE: Eltrombopag is the first oral, small-molecule, non-peptide thrombopoietin receptor agonist for the treatment of idiopathic thrombocytopenic purpura. This study investigated the pharmacokinetics of eltrombopag in healthy Chin...
Cytochrome P-450 CYP1A2 Pyrazoles Benzoates Sex Factors Hydrazines Neural Networks, Computer Female Polymorphism, Single Nucleotide Humans Genotype Male Asian People Young Adult Adolescent Tandem Mass Spectrometry Chromatography, Liquid Adult
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Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.

European journal of drug metabolism and pharmacokinetics Dec 1, 2020
BACKGROUND AND OBJECTIVE: Deferasirox is an oral iron chelator used to reduce iron levels in iron-overloaded patients with transfusion-dependent anemia or non-transfusion-dependent thalassemia. This study investigated the effects of genetic polymorph...
Multidrug Resistance-Associated Protein 2 Cytochrome P-450 CYP1A1 Glucuronosyltransferase Multidrug Resistance-Associated Proteins Deferasirox Area Under Curve Adult Iron Chelating Agents Asian People Female Humans Male Polymorphism, Single Nucleotide Middle Aged Neural Networks, Computer Young Adult Half-Life Predictive Value of Tests Adolescent Cross-Over Studies Drug Compounding Healthy Volunteers Polymorphism, Genetic
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