AIMC Topic: Iron Chelating Agents

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Machine learning uncovers independently regulated modules in the Bacillus subtilis transcriptome.

Nature communications Dec 11, 2020
The transcriptional regulatory network (TRN) of Bacillus subtilis coordinates cellular functions of fundamental interest, including metabolism, biofilm formation, and sporulation. Here, we use unsupervised machine learning to modularize the transcrip...
Quorum Sensing Gene Expression Regulation, Bacterial Iron Chelating Agents Gene Regulatory Networks Histidine Bacillus subtilis Data Mining Ethanol Tryptophan DNA Damage Machine Learning Transcriptome Bacterial Proteins
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A simple LC-MS/MS method for determination of deferasirox in human plasma: Troubleshooting of interference from ferric ion in method development and its application.

Journal of pharmaceutical and biomedical analysis Dec 28, 2017
As an orally active iron chelator, deferasirox forms its ion complexes in the prepared plasma samples and LC-MS mobile phase where ferric ion exists, and then comparing with the nominal concentration level, a lower detected concentration level of def...
Chromatography, Liquid Iron Chelating Agents Spectrometry, Mass, Electrospray Ionization Deferasirox Humans Tandem Mass Spectrometry Triazoles Ferric Compounds Benzoates
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Thermal and Antioxidant Properties of Polysaccharides Sequentially Extracted from Mulberry Leaves (Morus alba L.).

Molecules (Basel, Switzerland) Dec 20, 2017
Polysaccharides from natural plant products are gaining considerable attention due to their multi-faceted health effects, as well their functional applications in food production. We reported the sequential extraction of mulberry leaf polysaccharides...
Morus Monosaccharides Free Radical Scavengers Hydroxyl Radical Humans Polysaccharides Plant Extracts Fruit Plant Leaves Iron Iron Chelating Agents Temperature Thermodynamics Antioxidants
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Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.

European journal of drug metabolism and pharmacokinetics Dec 1, 2020
BACKGROUND AND OBJECTIVE: Deferasirox is an oral iron chelator used to reduce iron levels in iron-overloaded patients with transfusion-dependent anemia or non-transfusion-dependent thalassemia. This study investigated the effects of genetic polymorph...
Female Young Adult Humans Neural Networks, Computer Middle Aged Adolescent Adult Male Deferasirox Iron Chelating Agents Drug Compounding Polymorphism, Genetic Multidrug Resistance-Associated Protein 2 Cytochrome P-450 CYP1A1 Glucuronosyltransferase Multidrug Resistance-Associated Proteins Asian People Cross-Over Studies Healthy Volunteers Half-Life Polymorphism, Single Nucleotide Predictive Value of Tests Area Under Curve
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