AIMC Topic: Cytochrome P-450 CYP1A1

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Discovery of CYP1A1 Inhibitors for Host-Directed Therapy against Sepsis.

Journal of medicinal chemistry May 29, 2025
Bacterial sepsis remains a leading cause of death globally, exacerbated by the rise of multidrug resistance (MDR). Host-directed therapy (HDT) has emerged as a promising nonantibiotic approach to combat infections; thus, multiple HDT targets have bee...
Mice Methicillin-Resistant Staphylococcus aureus Microbial Sensitivity Tests Macrophages Animals Drug Discovery Acinetobacter baumannii Sepsis Structure-Activity Relationship Cytochrome P-450 CYP1A1 Humans Anti-Bacterial Agents Phagocytosis
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Machine learning algorithm-based risk prediction model of coronary artery disease.

Molecular biology reports Jul 11, 2018
In view of high mortality associated with coronary artery disease (CAD), development of an early predicting tool will be beneficial in reducing the burden of the disease. The database comprising demographic, conventional, folate/xenobiotic genetic ri...
Xenobiotics Cytochrome P-450 CYP1A1 Glycine Hydroxymethyltransferase Male Middle Aged Epistasis, Genetic Forecasting Machine Learning Adult Multifactor Dimensionality Reduction Female Algorithms Humans Folic Acid Case-Control Studies Polymorphism, Single Nucleotide Risk Factors Genetic Predisposition to Disease Coronary Artery Disease Aged
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Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.

European journal of drug metabolism and pharmacokinetics Dec 1, 2020
BACKGROUND AND OBJECTIVE: Deferasirox is an oral iron chelator used to reduce iron levels in iron-overloaded patients with transfusion-dependent anemia or non-transfusion-dependent thalassemia. This study investigated the effects of genetic polymorph...
Polymorphism, Genetic Deferasirox Drug Compounding Multidrug Resistance-Associated Proteins Multidrug Resistance-Associated Protein 2 Iron Chelating Agents Glucuronosyltransferase Asian People Cross-Over Studies Healthy Volunteers Half-Life Humans Predictive Value of Tests Area Under Curve Polymorphism, Single Nucleotide Cytochrome P-450 CYP1A1 Adult Male Middle Aged Neural Networks, Computer Female Adolescent Young Adult
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