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Cytochrome P-450 CYP1A1

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Machine learning algorithm-based risk prediction model of coronary artery disease.

Molecular biology reports 29995270
In view of high mortality associated with coronary artery disease (CAD), development of an early predicting tool will be beneficial in reducing the burden of the disease. The database comprising demographic, conventional, folate/xenobiotic genetic ri...
Adult Aged Algorithms Case-Control Studies Coronary Artery Disease Cytochrome P-450 CYP1A1 Epistasis, Genetic Female Folic Acid Forecasting Genetic Predisposition to Disease Glycine Hydroxymethyltransferase Humans Machine Learning Male Middle Aged Multifactor Dimensionality Reduction Polymorphism, Single Nucleotide Risk Factors Xenobiotics
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Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.

European journal of drug metabolism and pharmacokinetics 32930952
BACKGROUND AND OBJECTIVE: Deferasirox is an oral iron chelator used to reduce iron levels in iron-overloaded patients with transfusion-dependent anemia or non-transfusion-dependent thalassemia. This study investigated the effects of genetic polymorph...
Adolescent Adult Area Under Curve Asian People Cross-Over Studies Cytochrome P-450 CYP1A1 Deferasirox Drug Compounding Female Glucuronosyltransferase Half-Life Healthy Volunteers Humans Iron Chelating Agents Male Middle Aged Multidrug Resistance-Associated Protein 2 Multidrug Resistance-Associated Proteins Neural Networks, Computer Polymorphism, Genetic Polymorphism, Single Nucleotide Predictive Value of Tests Young Adult
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