AIMC Topic: Acinetobacter baumannii

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Modeling Antibacterial Activity with Machine Learning and Fusion of Chemical Structure Information with Microorganism Metabolic Networks.

Journal of chemical information and modeling Mar 4, 2019
Predicting the activity of new chemical compounds over pathogenic microorganisms with different metabolic reaction networks (MRN ) is an important goal due to the different susceptibility to antibiotics. The ChEMBL database contains >160 000 outcomes...
Microbial Sensitivity Tests Metabolic Networks and Pathways Machine Learning Anti-Bacterial Agents Enterococcus faecium Models, Biological Acinetobacter baumannii
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Pathogen Identification Direct From Polymicrobial Specimens Using Membrane Glycolipids.

Scientific reports Oct 26, 2018
With the increased prevalence of multidrug-resistant Gram-negative bacteria, the use of colistin and other last-line antimicrobials is being revisited clinically. As a result, there has been an emergence of colistin-resistant bacterial species, inclu...
Colistin Glycolipids Area Under Curve Acinetobacter baumannii Drug Resistance, Multiple, Bacterial ROC Curve Klebsiella pneumoniae Mass Spectrometry Anti-Bacterial Agents Databases, Factual Humans Machine Learning
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Design and synthesis of cell selective α/β-diastereomeric peptidomimetic with potent in vivo antibacterial activity against methicillin resistant S. Aureus.

Bioorganic chemistry Dec 26, 2017
Design of therapeutically viable antimicrobial peptides with cell selectivity against microorganisms is an important step towards the development of new antimicrobial agents. Here, we report four de novo designed, short amphipathic sequences based on...
Keratinocytes Phosphatidylglycerols Enterococcus faecalis Stereoisomerism Microbial Sensitivity Tests Lipid Bilayers Amino Acid Sequence Female Methicillin-Resistant Staphylococcus aureus Escherichia coli Peptidomimetics Pseudomonas aeruginosa Acinetobacter baumannii Animals Mice, Inbred BALB C Phosphatidylcholines Humans Hemolysis Erythrocytes Anti-Bacterial Agents
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Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents.

Bioorganic & medicinal chemistry letters Dec 29, 2016
Microbial resistance to antibiotics is a global concern. The World Health Organization (WHO) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. Without urgent and coordinated action, the wo...
Anti-Infective Agents Molecular Docking Simulation Pyrazoles Microbial Sensitivity Tests Gram-Negative Bacteria Gram-Positive Bacteria Drug Resistance, Multiple, Bacterial Acinetobacter baumannii Structure-Activity Relationship Binding Sites Benzoic Acid Catalytic Domain
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A Deep Learning Approach to Antibiotic Discovery.

Cell Feb 20, 2020
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed pr...
Mycobacterium tuberculosis Acinetobacter baumannii Anti-Bacterial Agents Mice, Inbred BALB C Animals Mice, Inbred C57BL Drug Discovery Machine Learning Small Molecule Libraries Mice Databases, Chemical Cheminformatics Clostridioides difficile Thiadiazoles
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