AIMC Topic: Lipoylation
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Intestinal permeability of N-acetylcysteine is driven by gut microbiota-dependent cysteine palmitoylation.
Nature communications
May 19, 2025
Trillions of intestinal microbiota are essential to the permeability of orally administered drugs. However, identifying microbial-drug interactions remains challenging due to the highly variable composition of intestinal flora among individuals. Usin...
Palmitoylation-related gene ZDHHC22 as a potential diagnostic and immunomodulatory target in Alzheimer's disease: insights from machine learning analyses and WGCNA.
European journal of medical research
Jan 22, 2025
BACKGROUND: The mechanism of palmitoylation in the pathogenesis of Alzheimer's disease (AD) remains unclear.
Predicting lysine lipoylation sites using bi-profile bayes feature extraction and fuzzy support vector machine algorithm.
Analytical biochemistry
Sep 12, 2018
Lipoylation is a highly conserved post-translational modification which has been found to be involved in many biological processes and closely associated with various metabolic diseases. The accurate identification of lipoylation sites is necessary t...
A machine-learning approach for predicting palmitoylation sites from integrated sequence-based features.
Journal of bioinformatics and computational biology
Jun 14, 2016
Palmitoylation is the covalent attachment of lipids to amino acid residues in proteins. As an important form of protein posttranslational modification, it increases the hydrophobicity of proteins, which contributes to the protein transportation, orga...
Insights into a Machine Learning-Based Palmitoylation-Related Gene Model for Predicting the Prognosis and Treatment Response of Breast Cancer Patients.
Technology in cancer research & treatment
Jan 1, 2024
BACKGROUND: Breast cancer is a prevalent public health concern affecting numerous women globally and is associated with palmitoylation, a post-translational protein modification. Despite increasing focus on palmitoylation, its specific implications f...
GPS-Palm: a deep learning-based graphic presentation system for the prediction of S-palmitoylation sites in proteins.
Briefings in bioinformatics
Mar 22, 2021
As an important reversible lipid modification, S-palmitoylation mainly occurs at specific cysteine residues in proteins, participates in regulating various biological processes and is associated with human diseases. Besides experimental assays, compu...
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