AIMC Topic: Adrenergic beta-2 Receptor Agonists

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Step up to triple therapy versus switch to dual bronchodilator therapy in patients with COPD on an inhaled corticosteroid/long-acting β-agonist: post-hoc analyses of KRONOS.

Respiratory research May 8, 2025
BACKGROUND: In people with chronic obstructive pulmonary disease (COPD) on inhaled corticosteroid/long-acting β-agonist (ICS/LABA) therapy, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends stepping up to ICS/long-acting mu...
Humans Female Aged Pulmonary Disease, Chronic Obstructive Male Middle Aged Treatment Outcome Drug Combinations Double-Blind Method Drug Therapy, Combination Drug Substitution Muscarinic Antagonists Adrenal Cortex Hormones Administration, Inhalation Bronchodilator Agents Adrenergic beta-2 Receptor Agonists
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Experimental drugs in clinical trials for COPD: artificial intelligence via machine learning approach to predict the successful advance from early-stage development to approval.

Expert opinion on investigational drugs Jul 6, 2023
INTRODUCTION: Therapeutic advances in drug therapy of chronic obstructive pulmonary disease (COPD) really effective in suppressing the pathological processes underlying the disease deterioration are still needed. Artificial Intelligence (AI) via Mach...
Humans Artificial Intelligence Machine Learning Pulmonary Disease, Chronic Obstructive Bayes Theorem Muscarinic Antagonists Administration, Inhalation Bronchodilator Agents Adrenergic beta-2 Receptor Agonists
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A randomised, phase III trial of once-daily fluticasone furoate/vilanterol 100/25 μg versus once-daily vilanterol 25 μg to evaluate the contribution on lung function of fluticasone furoate in the combination in patients with COPD.

Respiratory medicine Dec 2, 2016
BACKGROUND: The contribution of fluticasone furoate (FF) on lung function in the FF/vilanterol (VI) 100/25 μg combination has been demonstrated numerically, but not statistically.
Humans Female Aged Adult Pulmonary Disease, Chronic Obstructive Male Middle Aged Glucocorticoids Quality of Life Drug Combinations Double-Blind Method Forced Expiratory Volume Drug Administration Schedule Kaplan-Meier Estimate Administration, Inhalation Androstadienes Adrenergic beta-2 Receptor Agonists Benzyl Alcohols Chlorobenzenes
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