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Androstadienes

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Comparison of Changes in the Lipid Profiles of Eastern Chinese Postmenopausal Women With Early-Stage Breast Cancer Treated With Different Aromatase Inhibitors: A Retrospective Study.

Clinical pharmacology in drug development 29287126
Cardiovascular morbidity is closely associated with serum lipid level. We aimed to investigate the effects of different aromatase inhibitors, including letrozole, anastrozole, and exemestane, on the lipid profile of eastern Chinese breast cancer pati...
Aged Anastrozole Androstadienes Aromatase Inhibitors Asian People Breast Neoplasms China Female Humans Letrozole Lipid Metabolism Lipids Middle Aged Postmenopause Retrospective Studies
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A randomised, phase III trial of once-daily fluticasone furoate/vilanterol 100/25 μg versus once-daily vilanterol 25 μg to evaluate the contribution on lung function of fluticasone furoate in the combination in patients with COPD.

Respiratory medicine 28137501
BACKGROUND: The contribution of fluticasone furoate (FF) on lung function in the FF/vilanterol (VI) 100/25 μg combination has been demonstrated numerically, but not statistically.
Administration, Inhalation Adrenergic beta-2 Receptor Agonists Adult Aged Androstadienes Benzyl Alcohols Chlorobenzenes Double-Blind Method Drug Administration Schedule Drug Combinations Female Forced Expiratory Volume Glucocorticoids Humans Kaplan-Meier Estimate Male Middle Aged Pulmonary Disease, Chronic Obstructive Quality of Life
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Pharmacokinetics, Safety, and Tolerability of Once-Daily Intranasal Fluticasone Furoate and Levocabastine Administered Alone or Simultaneously as fluticasone Furoate/Levocabastine Fixed-Dose Combination.

Clinical pharmacology in drug development 27163502
PURPOSE: The purpose of this study was to investigate potential systemic pharmacokinetic interactions between intranasal fluticasone furoate (FF) and levocabastine (LEVO) when delivered simultaneously via a metered atomizing spray pump.
Administration, Intranasal Adult Androstadienes Biological Availability Cross-Over Studies Drug Combinations Female Glucocorticoids Histamine H1 Antagonists, Non-Sedating Humans Male Middle Aged Piperidines Young Adult
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Integration of a prognostic gene module with a drug sensitivity module to identify drugs that could be repurposed for breast cancer therapy.

Computers in biology and medicine 25596797
BACKGROUND: Efficiently discovering low risk drugs is important for drug development. However, the heterogeneity in patient population complicates the prediction of the therapeutic efficiency. Drug repositioning aiming to discover new indications of ...
Androstadienes Breast Neoplasms Databases, Genetic Female Gene Ontology Humans Pharmacogenetics Prognosis Tamoxifen
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