AIMC Topic: Aged, 80 and over

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Unified AI framework to uncover deep interrelationships between gene expression and Alzheimer's disease neuropathologies.

Nature communications Sep 10, 2021
Deep neural networks (DNNs) capture complex relationships among variables, however, because they require copious samples, their potential has yet to be fully tapped for understanding relationships between gene expression and human phenotypes. Here we...
RNA-Seq Mice Microglia Alzheimer Disease Sex Factors Aged, 80 and over Animals Male Deep Learning Cohort Studies Datasets as Topic Gene Expression Regulation Humans Brain Female Aged
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Discrimination of vascular aging using the arterial pulse spectrum and machine-learning analysis.

Microvascular research Sep 8, 2021
Aging contributes to the progression of vascular dysfunction and is a major nonreversible risk factor for cardiovascular disease. The aim of this study was to determine the effectiveness of using arterial pulse-wave measurements, frequency-domain pul...
Peripheral Arterial Disease Predictive Value of Tests Supervised Machine Learning Arterial Pressure Radial Artery Pulsatile Flow Male Aging Middle Aged Blood Pressure Determination Age Factors Female Reproducibility of Results Aged Aged, 80 and over Adult Humans
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Clinically relevant deep learning for detection and quantification of geographic atrophy from optical coherence tomography: a model development and external validation study.

The Lancet. Digital health Sep 8, 2021
BACKGROUND: Geographic atrophy is a major vision-threatening manifestation of age-related macular degeneration, one of the leading causes of blindness globally. Geographic atrophy has no proven treatment or method for easy detection. Rapid, reliable,...
Humans Reproducibility of Results Aged Aged, 80 and over Middle Aged Image Interpretation, Computer-Assisted Geographic Atrophy Deep Learning Tomography, Optical Coherence Retina
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Stratifying the Risk of Cardiovascular Disease in Obstructive Sleep Apnea Using Machine Learning.

The Laryngoscope Sep 6, 2021
OBJECTIVES/HYPOTHESIS: Obstructive sleep apnea (OSA) is associated with higher risk of morbidity and mortality related to cardiovascular disease (CVD). Due to overlapping clinical risk factors, identifying high-risk patients with OSA who are likely t...
Retrospective Studies Female Risk Factors Aged Aged, 80 and over Sensitivity and Specificity Humans Machine Learning Algorithms Sleep Apnea, Obstructive Male Cardiovascular Diseases Middle Aged Risk Assessment ROC Curve
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A machine learning-based biological aging prediction and its associations with healthy lifestyles: the Dongfeng-Tongji cohort.

Annals of the New York Academy of Sciences Sep 3, 2021
This study aims to establish a biological age (BA) predictor and to investigate the roles of lifestyles on biological aging. The 14,848 participants with the available information of multisystem measurements from the Dongfeng-Tongji cohort were used ...
Female Aged Follow-Up Studies Aged, 80 and over Principal Component Analysis Adult Aging Smoking Male Middle Aged Alcohol Drinking Humans Exercise Healthy Lifestyle Machine Learning China Forecasting Cohort Studies Prospective Studies
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Efficacy of a comprehensive binary classification model using a deep convolutional neural network for wireless capsule endoscopy.

Scientific reports Sep 1, 2021
The manual reading of capsule endoscopy (CE) videos in small bowel disease diagnosis is time-intensive. Algorithms introduced to automate this process are premature for real clinical applications, and multi-diagnosis using these methods has not been ...
Humans Neural Networks, Computer Algorithms Prognosis Retrospective Studies Male Middle Aged Adolescent Follow-Up Studies Capsule Endoscopy Intestinal Diseases Female Aged Aged, 80 and over Young Adult Adult
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Machine Learning-Based Radiomics Signatures for EGFR and KRAS Mutations Prediction in Non-Small-Cell Lung Cancer.

International journal of molecular sciences Aug 26, 2021
Early identification of epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations is crucial for selecting a therapeutic strategy for patients with non-small-cell lung cancer (NSCLC). We proposed a machin...
Middle Aged Female Humans Mutation ROC Curve Machine Learning Supervised Machine Learning Reproducibility of Results Lung Neoplasms Algorithms ErbB Receptors Aged Carcinoma, Non-Small-Cell Lung Biomarkers Proto-Oncogene Proteins p21(ras) Aged, 80 and over Neoplasm Staging Tomography, X-Ray Computed Male
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DeepAtrophy: Teaching a neural network to detect progressive changes in longitudinal MRI of the hippocampal region in Alzheimer's disease.

NeuroImage Aug 24, 2021
Measures of change in hippocampal volume derived from longitudinal MRI are a well-studied biomarker of disease progression in Alzheimer's disease (AD) and are used in clinical trials to track therapeutic efficacy of disease-modifying treatments. Howe...
Aged, 80 and over Male Disease Progression Cognitive Dysfunction Longitudinal Studies Humans Neural Networks, Computer Algorithms Biomarkers Female Aged Magnetic Resonance Imaging Alzheimer Disease Hippocampus Neuroimaging Atrophy
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A machine learning approach for the factorization of psychometric data with application to the Delis Kaplan Executive Function System.

Scientific reports Aug 19, 2021
While a replicability crisis has shaken psychological sciences, the replicability of multivariate approaches for psychometric data factorization has received little attention. In particular, Exploratory Factor Analysis (EFA) is frequently promoted as...
Adolescent Principal Component Analysis Factor Analysis, Statistical Databases as Topic Executive Function Young Adult Adult Humans Male Machine Learning Middle Aged Algorithms Psychometrics Female Aged Aged, 80 and over
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Evaluation of the feasibility of explainable computer-aided detection of cardiomegaly on chest radiographs using deep learning.

Scientific reports Aug 19, 2021
We examined the feasibility of explainable computer-aided detection of cardiomegaly in routine clinical practice using segmentation-based methods. Overall, 793 retrospectively acquired posterior-anterior (PA) chest X-ray images (CXRs) of 793 patients...
Humans Neural Networks, Computer Female Reproducibility of Results Aged Aged, 80 and over Young Adult Adult Male Image Processing, Computer-Assisted Middle Aged Area Under Curve Feasibility Studies Diagnosis, Computer-Assisted Cardiomegaly Deep Learning Thorax Adolescent Child ROC Curve
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