BACKGROUND: The improvement of health indicators and life expectancy, especially in developed countries, has led to population growth and increased age-related diseases, including Alzheimer's disease (AD). Thus, the early detection of AD is valuable ...
Brain aging is accompanied by patterns of functional and structural change. Alzheimer's disease (AD), a representative neurodegenerative disease, has been linked to accelerated brain aging. Here, we developed a deep learning-based brain age predictio...
Advanced materials (Deerfield Beach, Fla.)
May 4, 2022
The development of simple and accurate methods to predict mutations in proteins remains an unsolved challenge in modern biochemistry. It is discovered that critical information about primary and secondary peptide structures can be inferred from the s...
Early diagnosis and therapeutic intervention for Alzheimer's disease (AD) is currently the only viable option for improving clinical outcomes. Combining structural magnetic resonance imaging (sMRI) and resting-state functional magnetic resonance imag...
Increasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic Alzheimer's Disease (AD) with sex differences. This study aimed to determine the effect of ...
Early and accurate diagnosis of Alzheimer's disease (AD) and its prodromal period mild cognitive impairment (MCI) is essential for the delayed disease progression and the improved quality of patients' life. The emerging computer-aided diagnostic meth...
Research on segmentation of the hippocampus in magnetic resonance images through deep learning convolutional neural networks (CNNs) shows promising results, suggesting that these methods can identify small structural abnormalities of the hippocampus,...
BACKGROUND: The three core pathologies of Alzheimer's disease (AD) are amyloid pathology, tau pathology, and neurodegeneration. Biomarkers exist for each. Neurodegeneration is often detected by neuroimaging, and we hypothesized that a voxel-based dee...
The joint model for longitudinal and survival data improves time-to-event predictions by including longitudinal outcome variables in addition to baseline covariates. However, in practice, joint models may be limited by parametric assumptions in both ...
Alzheimer's disease (AD) is a neurodegenerative disease involving the decline of cognitive ability with illness progresses. At present, the diagnosis of AD mainly depends on the interviews between patients and doctors, which is slow, expensive, and s...