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Amino Acid Substitution

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Interaction of Vitamin E Intake and Pro12Ala Polymorphism of PPARG with Adiponectin Levels.

Journal of nutrigenetics and nutrigenomics 29402778
BACKGROUND/AIM: One of the beneficial effects associated with vitamin E intake is the enhancement of peroxisome proliferator-activated receptor gamma (PPARγ) activity and the consequent upregulation of adiponectin expression. The aim of this study wa...
Adiponectin Adolescent Adult Amino Acid Substitution Cross-Sectional Studies Female Genotype Humans Male Middle Aged Nutrigenomics Polymorphism, Single Nucleotide PPAR gamma Vitamin E Young Adult
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Applying an artificial neural network model for developing a severity score for patients with hereditary amyloid polyneuropathy.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 28719236
Hereditary (familial) amyloid polyneuropathy (FAP) is a systemic disease that includes a sensorimotor polyneuropathy related to transthyretin (TTR) mutations. So far, a scale designed to classify the severity of this disease has not yet been validate...
Amino Acid Substitution Amyloid Neuropathies, Familial Female Humans Male Models, Biological Mutation, Missense Neural Networks, Computer Prealbumin Severity of Illness Index
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modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly.

The Journal of biological chemistry 28924046
To understand the mechanism for assembly of Lys-linked polyubiquitin degradation signals, we previously demonstrated that the E6AP/UBE3A ligase harbors two functionally distinct E2∼ubiquitin-binding sites: a high-affinity Site 1 required for E6AP Cys...
Amino Acid Substitution Animals Binding Sites Biocatalysis Cattle Computational Biology Cysteine Expert Systems Humans Iodine Radioisotopes Isoenzymes Models, Molecular Molecular Docking Simulation Mutagenesis, Site-Directed Point Mutation Protein Conformation Protein Multimerization Recombinant Fusion Proteins Ubiquitin Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Ubiquitination
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Predicting the Effect of Single and Multiple Mutations on Protein Structural Stability.

Molecules (Basel, Switzerland) 29382060
Predicting how a point mutation alters a protein's stability can guide pharmaceutical drug design initiatives which aim to counter the effects of serious diseases. Conducting mutagenesis studies in physical proteins can give insights about the effect...
Amino Acid Substitution Computer Simulation Decision Trees Mutation Neural Networks, Computer Protein Conformation Protein Stability Proteins Support Vector Machine Thermodynamics
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An in-silico method for identifying aggregation rate enhancer and mitigator mutations in proteins.

International journal of biological macromolecules 29949748
Newly synthesized polypeptides must pass stringent quality controls in cells to ensure appropriate folding and function. However, mutations, environmental stresses and aging can reduce efficiencies of these controls, leading to accumulation of protei...
Algorithms Amino Acid Substitution Mutation, Missense Protein Structure, Secondary Proteins Support Vector Machine
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A systematic exploration of [Formula: see text] cutoff ranges in machine learning models for protein mutation stability prediction.

Journal of bioinformatics and computational biology 30419784
Discerning how a mutation affects the stability of a protein is central to the study of a wide range of diseases. Mutagenesis experiments on physical proteins provide precise insights about the effects of amino acid substitutions, but such studies ar...
Algorithms Amino Acid Substitution Computational Biology Machine Learning Mutation Neural Networks, Computer Protein Stability Proteins Random Allocation Support Vector Machine
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Computational and artificial neural network based study of functional SNPs of human LEPR protein associated with reproductive function.

Journal of cellular biochemistry 31237021
Genetic polymorphisms are mostly associated with inherited diseases, detecting and analyzing the biological significance of functional single-nucleotide polymorphisms (SNPs) using wet laboratory experiments is an arduous task hence the computational ...
Amino Acid Substitution Humans Infertility Molecular Docking Simulation Mutation, Missense Neural Networks, Computer Polymorphism, Single Nucleotide Protein Domains Receptors, Leptin
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Detection of the BRAF V600E Mutation in Colorectal Cancer by NIR Spectroscopy in Conjunction with Counter Propagation Artificial Neural Network.

Molecules (Basel, Switzerland) 31208050
This paper proposes a sensitive, sample preparation-free, rapid, and low-cost method for the detection of the B-rapidly accelerated fibrosarcoma (BRAF) gene mutation involving a substitution of valine to glutamic acid at codon 600 (V600E) in colorect...
Alleles Amino Acid Substitution Colorectal Neoplasms DNA Mutational Analysis Humans Mutation Neural Networks, Computer Proto-Oncogene Proteins B-raf Reproducibility of Results Spectroscopy, Near-Infrared
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