AIMC Topic: Animals

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Machine-Learning-Guided Peptide Drug Discovery: Development of GLP-1 Receptor Agonists with Improved Drug Properties.

Journal of medicinal chemistry
Peptide-based drug discovery has surged with the development of peptide hormone-derived analogs for the treatment of diabetes and obesity. Machine learning (ML)-enabled quantitative structure-activity relationship (QSAR) approaches have shown great p...

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori.

Signal transduction and targeted therapy
Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neural network-based deep learning model, ...

Measuring activity-rest rhythms under different acclimation periods in a marine fish using automatic deep learning-based video tracking.

Chronobiology international
Most organisms synchronize to an approximately 24-hour (circadian) rhythm. This study introduces a novel deep learning-powered video tracking method to assess the stability, fragmentation, robustness and synchronization of activity rhythms in . Exper...

Masked cross-domain self-supervised deep learning framework for photoacoustic computed tomography reconstruction.

Neural networks : the official journal of the International Neural Network Society
Accurate image reconstruction is crucial for photoacoustic (PA) computed tomography (PACT). Recently, deep learning has been used to reconstruct PA images with a supervised scheme, which requires high-quality images as ground truth labels. However, p...

Reconstructing Cancellous Bone From Down-Sampled Optical-Resolution Photoacoustic Microscopy Images With Deep Learning.

Ultrasound in medicine & biology
OBJECTIVE: Bone diseases deteriorate the microstructure of bone tissue. Optical-resolution photoacoustic microscopy (OR-PAM) enables high spatial resolution of imaging bone tissues. However, the spatiotemporal trade-off limits the application of OR-P...

Functional data geometric morphometrics with machine learning for craniodental shape classification in shrews.

Scientific reports
This work proposes a functional data analysis approach for morphometrics in classifying three shrew species (S. murinus, C. monticola, and C. malayana) from Peninsular Malaysia. Functional data geometric morphometrics (FDGM) for 2D landmark data is i...

Development of an artificial neural network (ANN) for the prediction of a pilot scale mobile wastewater treatment plant performance.

Journal of environmental management
Productive activities such as pig farming are a fundamental part of the economy in Mexico. Unfortunately, because of this activity, large quantities of wastewater are generated that have a negative impact in the environment. This work shows an altern...

A mathematical theory of relational generalization in transitive inference.

Proceedings of the National Academy of Sciences of the United States of America
Humans and animals routinely infer relations between different items or events and generalize these relations to novel combinations of items. This allows them to respond appropriately to radically novel circumstances and is fundamental to advanced co...

Factorized visual representations in the primate visual system and deep neural networks.

eLife
Object classification has been proposed as a principal objective of the primate ventral visual stream and has been used as an optimization target for deep neural network models (DNNs) of the visual system. However, visual brain areas represent many d...

Expanding continual few-shot learning benchmarks to include recognition of specific instances.

PloS one
Continual learning and few-shot learning are important frontiers in progress toward broader Machine Learning (ML) capabilities. Recently, there has been intense interest in combining both. One of the first examples to do so was the Continual few-shot...