AIMC Topic: Antifungal Agents

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Antifungal properties and biocompatibility of silver nanoparticle coatings on silicone maxillofacial prostheses in vitro.

Journal of biomedical materials research. Part B, Applied biomaterials
Patients with facial prostheses suffer from yeast, Candida albicans, infections. This study aimed to determine the biocompatibility and antifungal properties of silicone facial prostheses coated with silver nanoparticles (Ag NPs) in vitro. Medical gr...

Evaluation of synergistic anticandidal and apoptotic effects of ferulic acid and caspofungin against Candida albicans.

Journal of food and drug analysis
This study aimed to investigate the synergy between anticandidal and apoptotic effects of ferulic acid and caspofungin against Candida albicans and Candida glabrata, with the help of a quantitative checkerboard microdilution assay using 3-(4,5-dimeth...

Predicting antimicrobial peptides with improved accuracy by incorporating the compositional, physico-chemical and structural features into Chou's general PseAAC.

Scientific reports
Antimicrobial peptides (AMPs) are important components of the innate immune system that have been found to be effective against disease causing pathogens. Identification of AMPs through wet-lab experiment is expensive. Therefore, development of effic...

Antifungal activity of sterols and dipsacus saponins isolated from Dipsacus asper roots against phytopathogenic fungi.

Pesticide biochemistry and physiology
The in vivo antifungal activity of crude extracts of Dipsacus asper roots was evaluated against the phytopathogenic fungi Botrytis cinerea, Colletotrichum coccodes, Blumeria graminis f. sp. hordei, Magnaporthe grisea, Phytophthora infestans, Puccinia...

Antifungal activity of Momordica charantia seed extracts toward the pathogenic fungus Fusarium solani L.

Journal of food and drug analysis
Momordica charantia L., a vegetable crop with high nutritional value, has been used as an antimutagenic, antihelminthic, anticancer, antifertility, and antidiabetic agent in traditional folk medicine. In this study, the antifungal activity of M. char...

Using Machine Learning Algorithms to Identify Key Predictors of Invasive Mold Infection Surveillance.

The Journal of infectious diseases
BACKGROUND: Invasive mold infections (IMI) can lead to severe morbidity and mortality, but routine public health surveillance is lacking. Although extensive evaluation is needed for clinical diagnosis, case classification prediction models may inform...

Recent research frontiers of heterocycles as antifungal Agents: Insights from the past five years.

European journal of medicinal chemistry
This review explores the growing global concern of fungal infections, particularly in immunocompromised individuals, and highlights the critical need for improved antifungal therapies. With the rise of multidrug-resistant strains, such as Candida aur...

Bioactive films with essential oils and machine learning for controlling Aspergillus niger growth and fumonisin B production in vitro.

International journal of food microbiology
Aspergillus niger is an important species in the fungal community of many foods and is one of the most significant microorganisms used in biotechnology. Some A. niger strains are capable of producing fumonisin B (FB) under certain conditions, but lit...

Deep Learning-Guided Discovery of Celestolide as a Natural Allosteric Inhibitor Targeting CYP51 and Its Application in Strawberry Preservation.

Journal of agricultural and food chemistry
Most CYP51 inhibitors act competitively and are prone to resistance, whereas allosteric inhibitors hold promise but are difficult to develop. In this study, we employed the neural relational inference framework alongside the Gaussian network-based de...

AI in fungal drug development: opportunities, challenges, and future outlook.

Frontiers in cellular and infection microbiology
The application of artificial intelligence (AI) in fungal drug development offers innovative strategies to address the escalating threat of fungal infections and the challenge of antifungal resistance. This review evaluates the current landscape of f...