BACKGROUND: Virtual Screening (VS) has emerged as an important tool in the drug development process, as it conducts efficient in silico searches over millions of compounds, ultimately increasing yields of potential drug leads. As a subset of Artifici...
Studies in health technology and informatics
Jan 1, 2018
Bayesian Networks (BNs) are often used for designing diagnosis decision support systems. They are a well-established method for reasoning under uncertainty and making inferences. But, eliciting the probabilities can be tedious and time-consuming espe...
Studies in health technology and informatics
Jan 1, 2018
We present a knowledge-base to represent collated infectious disease risk (IDR) knowledge. The knowledge is about personal and contextual risk of contracting an infectious disease obtained from declarative sources (e.g. Atlas of Human Infectious Dise...
Studies in health technology and informatics
Jan 1, 2018
Numerous diagnostic decisions are made every day by healthcare professionals. Bayesian networks can provide a useful aid to the process, but learning their structure from data generally requires the absence of missing data, a common problem in medica...
Journal of the American Medical Informatics Association : JAMIA
Nov 1, 2017
OBJECTIVE: Predictive analytics create opportunities to incorporate personalized risk estimates into clinical decision support. Models must be well calibrated to support decision-making, yet calibration deteriorates over time. This study explored the...
SAR and QSAR in environmental research
Oct 1, 2017
The cytochrome P450 (CYP) enzyme superfamily is involved in phase I metabolism which chemically modifies a variety of substrates via oxidative reactions to make them more water-soluble and easier to eliminate. Inhibition of these enzymes leads to und...
MOTIVATION: Recent CASP experiments have witnessed exciting progress on folding large-size non-humongous proteins with the assistance of co-evolution based contact predictions. The success is however anecdotal due to the requirement of the contact pr...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2017
We report in this paper an investigation of convolutional neural network (CNN) models for target prediction in time-locked image rapid serial visual presentation (RSVP) experiment. We investigated CNN models with 11 different designs of convolution f...
Water science and technology : a journal of the International Association on Water Pollution Research
Jul 1, 2017
This research focuses on the application of an artificial neural network (ANN) to predict the removal efficiency of tartrazine from simulated wastewater using a photocatalytic process under solar illumination. A program is developed in Matlab softwar...
Journal of Zhejiang University. Science. B
May 1, 2017
Jaundice is a common and complex clinical symptom potentially occurring in hepatology, general surgery, pediatrics, infectious diseases, gynecology, and obstetrics, and it is fairly difficult to distinguish the cause of jaundice in clinical practice,...
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