Long-term pharmacological treatment is the cornerstone of the management of bipolar disorder (BD). Clinicians typically select mood-stabilizing medications from among several options through trial and error. This process could be optimized by using r...
INTRODUCTION: Bipolar disorder (BD) and major depressive disorder (MDD) have overlapping clinical presentations which may make it difficult for clinicians to distinguish them potentially resulting in misdiagnosis. This study combined structural MRI a...
In a letter critiquing our manuscript, Takefuji highlights general pitfalls in machine learning, without directly engaging with our study. The comments provide generic advice rather than a specific critique of our methods or findings. Despite raising...
International journal of molecular sciences
Dec 3, 2024
Mental health disorders are devastating illnesses, often misdiagnosed due to overlapping clinical symptoms. Among these conditions, bipolar disorder, schizophrenia, and schizoaffective disorder are particularly difficult to distinguish, as they share...
Skorobogatov et al. developed supervised machine learning models to predict diagnoses and illness states in schizophrenia and bipolar disorder. However, their reliance on bootstrap forests and generalized regressions introduces significant biases in ...
BACKGROUND: The genetic determinants of peripartum depression (PPD) are not fully understood. Using a multi-polygenic score approach, we characterized the relationship between genome-wide information and the history of PPD in patients with mood disor...
BACKGROUND: Optimising maintenance drug treatment selection for people with bipolar disorder is challenging. There is some evidence that clinical and demographic features may predict response to lithium. However, attempts to personalise treatment cho...
OBJECTIVES: Interpatient variability in bipolar I depression (BP-D) symptoms challenges the ability to predict pharmacotherapeutic outcomes. A machine learning workflow was developed to predict remission after 8 weeks of pharmacotherapy (total score ...
Journal of imaging informatics in medicine
Sep 26, 2024
With the increasing prevalence of mental illness, accurate clinical diagnosis of mental illness is crucial. Compared with MRI, CT has the advantages of wide application, low price, short scanning time, and high patient cooperation. This study aims to...
Mood disorders, particularly bipolar disorder (BD) and major depressive disorder (MDD), manifest changes in brain structure that can be detected using structural magnetic resonance imaging (MRI). Although structural MRI is a promising diagnostic tool...
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