AIMC Topic: Calcium Signaling

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Detection of genetic cardiac diseases by Ca transient profiles using machine learning methods.

Scientific reports Jun 19, 2018
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have revolutionized cardiovascular research. Abnormalities in Ca transients have been evident in many cardiac disease models. We have shown earlier that, by exploiting computation...
Humans Machine Learning Models, Theoretical Mutation Calcium Myocytes, Cardiac Induced Pluripotent Stem Cells Calcium Signaling Ryanodine Receptor Calcium Release Channel
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Spatiotemporal calcium signaling patterns underlying opposing effects of histamine and TAS2R agonists in airway smooth muscle.

American journal of physiology. Lung cellular and molecular physiology Jul 1, 2025
Intracellular calcium (Ca) release via phospholipase C (PLC) following G-protein-coupled receptor (GPCR) activation is typically linked to membrane depolarization and airway smooth muscle (ASM) contraction. However, recent findings show that bitter t...
Humans Animals Receptors, G-Protein-Coupled Calcium Myocytes, Smooth Muscle Respiratory System Calcium Signaling Muscle, Smooth Chloroquine Taste Receptors, Type 2 Histamine Flufenamic Acid
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Smart Data Analytics approach to model Complex Biochemical Oscillations in Hippocampal Neurons.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Jul 1, 2018
Calcium spiking can be used for drug screening studies in pharmaceutical industries. However, performing experiments for multiple drugs and doses are highly expensive. The oscillatory behavior of calcium spiking data demonstrates extreme nonlinearity...
Neural Networks, Computer Algorithms Animals Fluorescence Data Science Microscopy, Confocal Rats Drug Evaluation, Preclinical Neurons Hippocampus Calcium Signaling
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A Model of a Synthetic Biological Communication Interface between Mammalian Cells and Mechatronic Systems.

IEEE transactions on nanobioscience Dec 1, 2016
The creation of communication interfaces between abiotic and biotic systems represents a significant research challenge. In this work, we design and model a system linking the biochemical signaling pathways of mammalian cells to the actions of a mobi...
Humans Animals Gene Regulatory Networks Mice Robotics Models, Biological Synthetic Biology Calcium Signaling
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