AIMC Topic: Calcium Signaling
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Efficient Position Decoding Methods Based on Fluorescence Calcium Imaging in the Mouse Hippocampus.
Neural computation
Apr 28, 2020
Large-scale fluorescence calcium imaging methods have become widely adopted for studies of long-term hippocampal and cortical neuronal dynamics. Pyramidal neurons of the rodent hippocampus show spatial tuning in freely foraging or head-fixed navigati...
Detection of genetic cardiac diseases by Ca transient profiles using machine learning methods.
Scientific reports
Jun 19, 2018
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have revolutionized cardiovascular research. Abnormalities in Ca transients have been evident in many cardiac disease models. We have shown earlier that, by exploiting computation...
Spatiotemporal calcium signaling patterns underlying opposing effects of histamine and TAS2R agonists in airway smooth muscle.
American journal of physiology. Lung cellular and molecular physiology
Jul 1, 2025
Intracellular calcium (Ca) release via phospholipase C (PLC) following G-protein-coupled receptor (GPCR) activation is typically linked to membrane depolarization and airway smooth muscle (ASM) contraction. However, recent findings show that bitter t...
Smart Data Analytics approach to model Complex Biochemical Oscillations in Hippocampal Neurons.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2018
Calcium spiking can be used for drug screening studies in pharmaceutical industries. However, performing experiments for multiple drugs and doses are highly expensive. The oscillatory behavior of calcium spiking data demonstrates extreme nonlinearity...
A Model of a Synthetic Biological Communication Interface between Mammalian Cells and Mechatronic Systems.
IEEE transactions on nanobioscience
Dec 1, 2016
The creation of communication interfaces between abiotic and biotic systems represents a significant research challenge. In this work, we design and model a system linking the biochemical signaling pathways of mammalian cells to the actions of a mobi...
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