AIMC Topic: Cell Culture Techniques
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Application of Artificial Intelligence to In Vitro Tumor Modeling and Characterization of the Tumor Microenvironment.
Advanced healthcare materials
Apr 26, 2023
In vitro tumor models have played vital roles in enhancing the understanding of the cellular and molecular composition of tumors, as well as their biochemical and biophysical characteristics. Advances in technology have enabled the evolution of tumor...
Data-driven prediction models for forecasting multistep ahead profiles of mammalian cell culture toward bioprocess digital twins.
Biotechnology and bioengineering
Apr 20, 2023
Recently, the advancement in process analytical technology and artificial intelligence (AI) has enabled the generation of enormous culture data sets from biomanufacturing processes that produce various recombinant therapeutic proteins (RTPs), such as...
An automated, low volume, and high-throughput analytical platform for aggregate quantitation from cell culture media.
Journal of chromatography. A
Jan 21, 2023
High throughput screening methods have driven a paradigm shift in biopharmaceutical development by reducing the costs of good manufactured (COGM) and accelerate the launch to market of novel drug products. Scale-down cell culture systems such as shak...
Neural Network in the Analysis of the MR Signal as an Image Segmentation Tool for the Determination of T and T Relaxation Times with Application to Cancer Cell Culture.
International journal of molecular sciences
Jan 13, 2023
Artificial intelligence has been entering medical research. Today, manufacturers of diagnostic instruments are including algorithms based on neural networks. Neural networks are quickly entering all branches of medical research and beyond. Analyzing ...
Fisheye transformation enhances deep-learning-based single-cell phenotyping by including cellular microenvironment.
Cell reports methods
Nov 21, 2022
Incorporating information about the surroundings can have a significant impact on successfully determining the class of an object. This is of particular interest when determining the phenotypes of cells, for example, in the context of high-throughput...
Characterization of drug effects on cell cultures from phase-contrast microscopy images.
Computers in biology and medicine
Oct 14, 2022
In this work, we classify chemotherapeutic agents (topoisomerase inhibitors) based on their effect on U-2 OS cells. We use phase-contrast microscopy images, which are faster and easier to obtain than fluorescence images and support live cell imaging....
Implementing robotics and artificial intelligence.
eLife
Jul 20, 2022
An automated platform for cell culture combines robotics and artificial intelligence to optimize cell culture protocols and reliably produce specific cell types that could be used for regenerative medicine treatments.
Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells.
Stem cell reports
Dec 2, 2021
Efficient translation of human induced pluripotent stem cells (hiPSCs) requires scalable cell manufacturing strategies for optimal self-renewal and functional differentiation. Traditional manual cell culture is variable and labor intensive, posing ch...
A deep learning approach to identify and segment alpha-smooth muscle actin stress fiber positive cells.
Scientific reports
Nov 8, 2021
Cardiac fibrosis is a pathological process characterized by excessive tissue deposition, matrix remodeling, and tissue stiffening, which eventually leads to organ failure. On a cellular level, the development of fibrosis is associated with the activa...
MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity.
Nature methods
Nov 1, 2021
Spheroids are three-dimensional cellular models with widespread basic and translational application across academia and industry. However, methodological transparency and guidelines for spheroid research have not yet been established. The MISpheroID ...
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