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Cognitive Dysfunction

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Ultra-Low-Dose F-Florbetaben Amyloid PET Imaging Using Deep Learning with Multi-Contrast MRI Inputs.

Radiology
Purpose To reduce radiotracer requirements for amyloid PET/MRI without sacrificing diagnostic quality by using deep learning methods. Materials and Methods Forty data sets from 39 patients (mean age ± standard deviation [SD], 67 years ± 8), including...

From cognitive and clinical substrates to functional profiles: Disentangling heterogeneity in schizophrenia.

Psychiatry research
The relationship between neurocognition and functioning among patients with schizophrenia is well documented. However, integrating neuropsychological, clinical and psychopathological data to better investigate functional outcome still constitutes a c...

Geoffrey: An Automated Schedule System on a Social Robot for the Intellectually Challenged.

Computational intelligence and neuroscience
The accelerated growth of the percentage of elder people and persons with brain injury-related conditions and who are intellectually challenged are some of the main concerns of the developed countries. These persons often require special cares and ev...

Novel Effective Connectivity Inference Using Ultra-Group Constrained Orthogonal Forward Regression and Elastic Multilayer Perceptron Classifier for MCI Identification.

IEEE transactions on medical imaging
Mild cognitive impairment (MCI) detection is important, such that appropriate interventions can be imposed to delay or prevent its progression to severe stages, including Alzheimer's disease (AD). Brain connectivity network inferred from the function...

A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using F-FDG PET of the Brain.

Radiology
Purpose To develop and validate a deep learning algorithm that predicts the final diagnosis of Alzheimer disease (AD), mild cognitive impairment, or neither at fluorine 18 (F) fluorodeoxyglucose (FDG) PET of the brain and compare its performance to t...

Effective feature learning and fusion of multimodality data using stage-wise deep neural network for dementia diagnosis.

Human brain mapping
In this article, the authors aim to maximally utilize multimodality neuroimaging and genetic data for identifying Alzheimer's disease (AD) and its prodromal status, Mild Cognitive Impairment (MCI), from normal aging subjects. Multimodality neuroimagi...

Learning to Detect Cognitive Impairment through Digital Games and Machine Learning Techniques.

Methods of information in medicine
OBJECTIVE: Alzheimer's disease (AD) is one of the most prevalent diseases among the adult population. The early detection of Mild Cognitive Impairment (MCI), which may trigger AD, is essential to slow down the cognitive decline process.

Instance-Based Representation Using Multiple Kernel Learning for Predicting Conversion to Alzheimer Disease.

International journal of neural systems
The early detection of Alzheimer's disease and quantification of its progression poses multiple difficulties for machine learning algorithms. Two of the most relevant issues are related to missing data and results interpretability. To deal with both ...

Temporal Correlation Structure Learning for MCI Conversion Prediction.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
In Alzheimer's research, Mild Cognitive Impairment (MCI) is an important intermediate stage between normal aging and Alzheimer's. How to distinguish MCI samples that finally convert to AD from those do not is an essential problem in the prevention an...