Cognitive frailty (CF), a clinical syndrome involving both physical frailty (PF) and impaired cognition (IC), is associated with adverse health outcomes in older adults. This study aimed to identify key predictors of CF and develop a machine learning...
BACKGROUND: Movement patterns, activity levels and circadian rhythm are altered in Alzheimer's disease (AD) and can be assessed by actigraphy using wearable sensors. We aimed to determine the diagnostic performance of actigraphy in AD in a memory cli...
Biomedical physics & engineering express
May 21, 2025
Alzheimer's disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia worldwide and remains incurable once it begins. Therefore, early and accurate diagnosis is essential for effective intervention. Leveraging recent ad...
Studies in health technology and informatics
May 12, 2025
Cognitive Reserve (CR) refers to the brain's ability to compensate for brain damage or age-related changes, which can explain why some individuals show greater cognitive resilience to brain pathology despite damage or age-related changes. Understandi...
BACKGROUND: Several potentially modifiable risk factors are associated with subjective cognitive decline (SCD). However, developmental patterns of these risk factors have not been used before to forecast later SCD. Practical tools for the prevention ...
White matter hyperintensities (WMH) are neuroimaging markers linked to an elevated risk of cognitive decline. WMH severity is typically assessed via visual rating scales and through volumetric segmentation. While visual rating scales are commonly use...
The international journal of neuropsychopharmacology
Apr 11, 2025
BACKGROUND: The global prevalence of dementia is significantly increasing. Early detection and prevention strategies, particularly for mild cognitive impairment (MCI), are crucial but currently hindered by the lack of established biomarkers. Here, we...
The progression of Alzheimer's disease (AD) involves complex changes in brain structure and function that are driven by their interaction, making structure-function coupling (SFC) a valuable indicator for early detection of AD. Static SFC refers to t...
Given the relationship between hippocampal atrophy and cognitive impairment in various pathological conditions, hippocampus segmentation from MRI is an important task in neuroimaging. Manual segmentation, though considered the gold standard, is time-...
OBJECTIVE: This study aims to develop and validate a machine learning model for identifying individuals within the nursing population experiencing severe subjective cognitive decline (SCD) during the menopause transition, along with their associated ...
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