Complement C1q

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Microglial pruning of glycinergic synapses disinhibits spinal PKCĪ³ interneurons to drive pain hypersensitivity in mice.

Science translational medicine Jun 18, 2025
Microglial activation is linked to neuroinflammation in neuropathic pain. Recently, microglia-mediated synaptic pruning has received mounting attention. However, the exact role of spinal microglia in modulating neuropathic pain-associated neural circ...
Animals Male Mice Mice, Inbred C57BL Microglia Glycine Synapses Spinal Cord Neuralgia Hyperalgesia Protein Kinase C Apolipoproteins E Interneurons Complement C1q
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Evaluation of the Classification Accuracy of the Kidney Biopsy Direct Immunofluorescence through Convolutional Neural Networks.

Clinical journal of the American Society of Nephrology : CJASN Sep 16, 2020
BACKGROUND AND OBJECTIVES: Immunohistopathology is an essential technique in the diagnostic workflow of a kidney biopsy. Deep learning is an effective tool in the elaboration of medical imaging. We wanted to evaluate the role of a convolutional neura...
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Humans Neural Networks, Computer Female Aged Adult Male Middle Aged ROC Curve Image Processing, Computer-Assisted Kidney Kidney Diseases Area Under Curve Biopsy Fibrinogen Immunoglobulins Complement C3 Fluorescent Antibody Technique, Direct Complement C1q Immunoglobulin kappa-Chains Immunoglobulin lambda-Chains
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