AIMC Topic: Computational Biology
Clear Filters Showing 131 to 140 of 4396 articles
GNNMutation: a heterogeneous graph-based framework for cancer detection.
BMC bioinformatics
Jun 4, 2025
BACKGROUND: When genes are translated into proteins, mutations in the gene sequence can lead to changes in protein structure and function as well as in the interactions between proteins. These changes can disrupt cell function and contribute to the d...
HLN-DDI: hierarchical molecular representation learning with co-attention mechanism for drug-drug interaction prediction.
BMC bioinformatics
Jun 4, 2025
BACKGROUND: Accurate identification of drug-drug interactions (DDIs) is critical in pharmacology, as DDIs can either enhance therapeutic efficacy or trigger adverse reactions when multiple medications are administered concurrently. Traditional method...
Efficient structure learning of gene regulatory networks with Bayesian active learning.
BMC bioinformatics
Jun 3, 2025
BACKGROUND: Gene regulatory network modeling is a complex structure learning problem that involves both observational data analysis and experimental interventions. Bayesian causal discovery provides a principled framework for modeling observational d...
NPI-HetGNN: A Prediction Model of ncRNA-Protein Interactions Based on Heterogeneous Graph Neural Networks.
Interdisciplinary sciences, computational life sciences
Jun 2, 2025
Non-coding RNAs (ncRNAs) are one of the components of epigenetic mechanisms that regulates gene expression. Studying ncRNA-protein interactions (NPI) can help to explore a wide range of biological features and related diseases. Traditional NPI resear...
Multi-view based heterogeneous graph contrastive learning for drug-target interaction prediction.
Journal of biomedical informatics
Jun 2, 2025
Drug-Target Interaction (DTI) prediction plays a pivotal role in accelerating drug discovery and development by identifying novel interactions between drugs and targets. Most previous studies on Drug-Protein Pair (DPP) networks have primarily focused...
READRetro web: A user-friendly platform for predicting plant natural product biosynthesis.
Molecules and cells
Jun 2, 2025
Natural products (NPs), a fundamental class of bioactive molecules with broad applicability, are valuable sources in pharmaceutical research and drug discovery. Despite their significance, the large-scale production of NPs is often limited by their a...
Exploration of the potential therapeutic effects and targets of Coriandrum sativum on non-erosive esophagitis based on bioinformatics and molecular dynamics simulation.
Scientific reports
May 31, 2025
Gastroesophageal reflux disease (GERD) is one of the most frequently diagnosed gastrointestinal disorders, adversely affecting quality of life. Coriandrum sativum has been shown to effectively promote gastrointestinal motility, alleviate gastric disc...
Prediction of Ligand-Receptor Interactions Based on CatBoost and Deep Forest and Their Application in Cell-Cell Communication Analysis.
Journal of chemical information and modeling
May 30, 2025
Cell-to-cell communication (CCC) is prominent for cell growth and development as well as tissue and organ formation. CCC inference can help us to deeply understand cellular interplay and discover potential therapeutic targets for complex diseases. Ce...
Integrated bioinformatics and network pharmacology to identify and validate macrophage polarization related hub genes in the treatment of osteoarthritis with Astragalus membranaceus.
Journal of orthopaedic surgery and research
May 30, 2025
BACKGROUND: Macrophage polarization exacerbates the pathological processes of osteoarthritis (OA). Astragalus membranaceus (AM) can repair chondrocytes and serve as a protective agent for OA. Therefore, the study intended to identify macrophage polar...
PRP: pathogenic risk prediction for rare nonsynonymous single nucleotide variants.
Human genetics
May 29, 2025
Reliable prediction of pathogenic variants plays a crucial role in personalized medicine, which aims to provide accurate diagnosis and individualized treatment using genomic medicine. This study introduces PRP, a pathogenic risk prediction for rare n...
Stay Ahead of Medical AI
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.
Subscribe NowPopular Topics
- Machine Learning 32510
- Neural Networks, Computer 30481
- Algorithms 27731
- Deep Learning 27277
- Artificial Intelligence 25203
- Robotics 13428
- Image Processing, Computer-Assisted 9883
- Retrospective Studies 9527
- Magnetic Resonance Imaging 6481
- Reproducibility of Results 5744
- Tomography, X-Ray Computed 4956
- Support Vector Machine 4812
- Computational Biology 4392
- Brain 4186
- Computer Simulation 3962
Recent Journals
- Scientific reports 7009
- Sensors (Basel, Switzerland) 4794
- PloS one 4295
- Neural networks : the official journal of the International Neural Network Society 3035
- Computers in biology and medicine 2037
- Computational intelligence and neuroscience 1931
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 1686
- Studies in health technology and informatics 1395
- IEEE journal of biomedical and health informatics 1191
- Journal of chemical information and modeling 1083
- Nature communications 1070
- Computer methods and programs in biomedicine 895
- Bioinformatics (Oxford, England) 879
- Journal of medical Internet research 878
- IEEE transactions on neural networks and learning systems 859