Proceedings of the National Academy of Sciences of the United States of America
Sep 23, 2025
Convergent evolution, or convergence, refers to repeated, independent emergences of the same trait in two or more lineages of species during evolution, often indicating functional adaptation to specific environmental factors. Many computational metho...
Bacteriophages offer a promising alternative to conventional antimicrobials, especially when such treatments fail. While natural phages are viable for therapy, advances in synthetic biology allow precise genome modifications to enhance their therapeu...
BACKGROUND: Tumor evolution, driven by the emergence of genetically and epigenetically distinct subclones, enables cancers to adapt to selective pressures and become more aggressive, posing a major challenge in oncology. Multi-regional sequencing has...
The identification of bitter peptides is crucial in various domains, including food science, drug discovery, and biochemical research. These peptides not only contribute to the undesirable taste of hydrolyzed proteins but also play key roles in physi...
Journal of chemical information and modeling
Sep 18, 2025
With the increasing discovery of peptide sequences and the growing demand for peptide-targeted drugs, traditional wet-lab experiment methods have become inadequate for peptide function prediction due to their high cost and that they are time consumin...
Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially expressed genes, and appl...
Biochemical and biophysical research communications
Sep 16, 2025
CircRNAs are ubiquitously expressed across diverse tissues and cells, playing a pivotal role not only in protein-mediated biological processes but also in disease prevention and therapeutics. RNA-RBP interactions are critical for deciphering gene reg...
Journal of chemical information and modeling
Sep 16, 2025
RNA molecules play diverse and critical roles in various biological processes, including gene expression, post-transcriptional regulation, and disease pathogenesis. Understanding the interaction between proteins and RNA necessitates the precise ident...
BACKGROUND: Variants of uncertain significance (VUS) represent a major diagnostic challenge in the interpretation of genetic testing results, particularly in the context of inborn errors of immunity such as severe combined immunodeficiency (SCID). Th...
Mass-based fingerprinting can characterize microorganisms; however, expansion of these methods to predict specific gene functions is lacking. Therefore, mass fingerprinting was developed to functionally profile a yeast knockout library. Matrix-assist...
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