Pharmacokinetic data are not generally available for evaluating the toxicological potential of food chemicals. A simplified physiologically based pharmacokinetic (PBPK) model has been established to evaluate internal exposures to chemicals in rats or...
Protein-protein interactions (PPIs) perform significant functions in many biological activities likewise gene regulation, metabolic pathways and signal transduction. The deregulation of PPIs may cause deadly diseases, such as cancer, autoimmune, pern...
Learning from others is an important adaptation. However, the evolution of social learning and its role in the spread of socially transmitted information are not well understood. Few models of social learning account for the fact that socially transm...
BACKGROUND: The risk stratification and prognosis of cardiac arrhythmia depend on the individual condition of patients, while invasive diagnostic methods may be risky to patient health, and current non-invasive diagnostic methods are applicable to fe...
The artificial lateral line system, composed of velocity and pressure sensors, is the sensing system for fish-like robots by mimicking the lateral line system of aquatic organisms. However, accurately estimating the self-motion of the fish-like robot...
Entomopathogenic nematodes (EPNs) exhibit a bending-elastic instability, or kink, before becoming airborne, a feature previously hypothesized but not substantiated to enhance jumping performance. Here, we provide the evidence that this kink is crucia...
Artificial intelligence (AI) has the potential to improve healthcare and patient safety and is currently being adopted across various fields of medicine and healthcare. AI and in particular computer vision (CV) are well suited to the analysis of mini...
Quantitative structure-activity relationship (QSAR) methods have emerged as powerful tools to streamline non-clinical pharmacokinetic (PK) studies, with extensive evidence demonstrating their potential to predict key in vivo PK parameters such as cle...
The study of brain activity spans diverse scales and levels of description and requires the development of computational models alongside experimental investigations to explore integrations across scales. The high dimensionality of spiking networks p...