AIMC Topic: Computer Simulation

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A novel in silico approach for predicting unbound brain-to-plasma ratio using machine learning-based support vector regression.

Computers in biology and medicine
The blood-brain barrier (BBB) functions as a vital protective mechanism, restricting the entry of substances and xenobiotics into the central nervous system (CNS). Consequently, BBB penetration is a critical aspect of absorption, distribution, metabo...

A Global Visual Information Intervention Model for Medical Visual Question Answering.

Computers in biology and medicine
Medical Visual Question Answering (Med-VQA) aims to furnish precise responses to clinical queries related to medical imagery. While its transformative potential in healthcare is undeniable, current solutions remain nascent and are yet to see widespre...

A deep learning framework leveraging spatiotemporal feature fusion for electrophysiological source imaging.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVES: Electrophysiological source imaging (ESI) is a challenging technique for noninvasively measuring brain activity, which involves solving a highly ill-posed inverse problem. Traditional methods attempt to address this challen...

Deep reinforcement learning for Type 1 Diabetes: Dual PPO controller for personalized insulin management.

Computers in biology and medicine
BACKGROUND: Managing blood glucose levels in Type 1 Diabetes Mellitus (T1DM) is essential to prevent complications. Traditional insulin delivery methods often require significant patient involvement, limiting automation. Reinforcement Learning (RL)-b...

Reinforcement learning using neural networks in estimating an optimal dynamic treatment regime in patients with sepsis.

Computer methods and programs in biomedicine
OBJECTIVE: Early fluid resuscitation is crucial in the treatment of sepsis, yet the optimal dosage remains debated. This study aims to determine the optimal multi-stage fluid resuscitation dosage for sepsis patients.

Toward Building Human-Like Sequential Memory Using Brain-Inspired Spiking Neural Models.

IEEE transactions on neural networks and learning systems
The brain is able to acquire and store memories of everyday experiences in real-time. It can also selectively forget information to facilitate memory updating. However, our understanding of the underlying mechanisms and coordination of these processe...

STSF: Spiking Time Sparse Feedback Learning for Spiking Neural Networks.

IEEE transactions on neural networks and learning systems
Spiking neural networks (SNNs) are biologically plausible models known for their computational efficiency. A significant advantage of SNNs lies in the binary information transmission through spike trains, eliminating the need for multiplication opera...

From human hand joints to continuum robot: how articular surface morphology shapes flexibility and stability in template-based designs.

Bioinspiration & biomimetics
The design of continuum robots often involves a dilemma between flexibility and stiffness, where increased flexibility may reduce stiffness and control precision. The human hand achieves both power grasp and precision grasp by leveraging different jo...

Development of time to event prediction models using federated learning.

BMC medical research methodology
BACKGROUND: In a wide range of diseases, it is necessary to utilize multiple data sources to obtain enough data for model training. However, performing centralized pooling of multiple data sources, while protecting each patients' sensitive data, can ...

Modeling rapid language learning by distilling Bayesian priors into artificial neural networks.

Nature communications
Humans can learn languages from remarkably little experience. Developing computational models that explain this ability has been a major challenge in cognitive science. Existing approaches have been successful at explaining how humans generalize rapi...