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Prediction and Prioritisation of Novel Anthelmintic Candidates from Public Databases Using Deep Learning and Available Bioactivity Data Sets.

International journal of molecular sciences
The control of socioeconomically important parasitic roundworms (nematodes) of animals has become challenging or ineffective due to problems associated with widespread resistance in these worms to most classes of chemotherapeutic drugs (anthelmintics...

Artificial intelligence driven platform for rapid catalytic performance assessment of nanozymes.

Scientific reports
Traditional methods for synthesizing nanozymes are often time-consuming and complex, hindering efficiency. Artificial intelligence (AI) has the potential to simplify these processes, but there are very few dedicated nanozyme databases available, limi...

A comprehensive case study of deep learning on the detection of alpha thalassemia and beta thalassemia using public and private datasets.

Scientific reports
This study explores the performance of deep learning models, specifically Convolutional Neural Networks (CNN) and XGBoost, in predicting alpha and beta thalassemia using both public and private datasets. Thalassemia is a genetic disorder that impairs...

BenchXAI: Comprehensive benchmarking of post-hoc explainable AI methods on multi-modal biomedical data.

Computers in biology and medicine
The increasing digitalization of multi-modal data in medicine and novel artificial intelligence (AI) algorithms opens up a large number of opportunities for predictive models. In particular, deep learning models show great performance in the medical ...

Atten-Nonlocal Unet: Attention and Non-local Unet for medical image segmentation.

Computers in biology and medicine
The convolutional neural network(CNN)-based models have emerged as the predominant approach for medical image segmentation due to their effective inductive bias. However, their limitation lies in the lack of long-range information. In this study, we ...

A multi-scale convolutional LSTM-dense network for robust cardiac arrhythmia classification from ECG signals.

Computers in biology and medicine
Cardiac arrhythmias are irregular heart rhythms that, if undetected, can lead to severe cardiovascular conditions. Detecting these anomalies early through electrocardiogram (ECG) signal analysis is critical for preventive healthcare and effective tre...

Multi-level feature fusion network for kidney disease detection.

Computers in biology and medicine
Kidney irregularities pose a significant public health challenge, often leading to severe complications, yet the limited availability of nephrologists makes early detection costly and time-consuming. To address this issue, we propose a deep learning ...

[Personalized mandibular reconstruction assisted by three-dimensional retrieval model based on fully connected neural network and a database of mandibles].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
OBJECTIVE: To propose a new protocol for personalized mandibular reconstruction assisted by three-dimensional (3D) retrieval model based on fully connected neural network (FCNN) and a database of mandibles, and to verify clinical feasibility of the p...

Transformer-based deep learning ensemble framework predicts autism spectrum disorder using health administrative and birth registry data.

Scientific reports
Early diagnosis and access to resources, support and therapy are critical for improving long-term outcomes for children with autism spectrum disorder (ASD). ASD is typically detected using a case-finding approach based on symptoms and family history,...

Identifying progression subphenotypes of Alzheimer's disease from large-scale electronic health records with machine learning.

Journal of biomedical informatics
OBJECTIVE: Identification of clinically meaningful subphenotypes of disease progression can enhance the understanding of disease heterogeneity and underlying pathophysiology. In this study, we propose a machine learning framework to identify subpheno...