Computational intelligence and neuroscience
Nov 29, 2016
For the shortcoming of fuzzy -means algorithm (FCM) needing to know the number of clusters in advance, this paper proposed a new self-adaptive method to determine the optimal number of clusters. Firstly, a density-based algorithm was put forward. The...
International journal of molecular sciences
Nov 22, 2016
Most cellular functions involve proteins' features based on their physical interactions with other partner proteins. Sketching a map of protein-protein interactions (PPIs) is therefore an important inception step towards understanding the basics of c...
Neural networks : the official journal of the International Neural Network Society
Nov 3, 2016
In this paper, we extend our previous work on the Enhanced Fuzzy Min-Max (EFMM) neural network by introducing a new hyperbox selection rule and a pruning strategy to reduce network complexity and improve classification performance. Specifically, a ne...
BACKGROUND: Alzheimer's disease (AD) is a complex progressive neurodegenerative disorder commonly characterized by short term memory loss. Presently no effective therapeutic treatments exist that can completely cure this disease. The cause of Alzheim...
Transmembrane proteins (TMPs) are important drug targets because they are essential for signaling, regulation, and transport. Despite important breakthroughs, experimental structure determination remains challenging for TMPs. Various methods have bri...
Journal of computational biology : a journal of computational molecular cell biology
Aug 16, 2016
BACKGROUND: There are many computational approaches to predict the protein-protein interactions using support vector machines (SVMs) with high performance. In fact, performance of currently reported methods are significantly over-estimated and affect...
The determination of the molecular formula is one of the earliest and most important steps when investigating the chemical nature of an unknown compound. Common approaches use the isotopic pattern of a compound measured using mass spectrometry. Compu...
Alzheimer's disease (AD) is an irreversible neurodegenerative disease and affects a large population in the world. Cognitive scores at multiple time points can be reliably used to evaluate the progression of the disease clinically. In recent studies,...
Psychiatric research has entered the age of 'Big Data'. Datasets now routinely involve thousands of heterogeneous variables, including clinical, neuroimaging, genomic, proteomic, transcriptomic and other 'omic' measures. The analysis of these dataset...
International journal of neural systems
Jun 26, 2016
Cognitive fault detection and diagnosis systems are systems able to provide timely information about possibly occurring faults without requiring any a priori knowledge about the process generating the data or the possible faults. This ability is cruc...
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