AIMC Topic: Datasets as Topic

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A Self-Adaptive Fuzzy -Means Algorithm for Determining the Optimal Number of Clusters.

Computational intelligence and neuroscience
For the shortcoming of fuzzy -means algorithm (FCM) needing to know the number of clusters in advance, this paper proposed a new self-adaptive method to determine the optimal number of clusters. Firstly, a density-based algorithm was put forward. The...

Prediction of Protein-Protein Interactions by Evidence Combining Methods.

International journal of molecular sciences
Most cellular functions involve proteins' features based on their physical interactions with other partner proteins. Sketching a map of protein-protein interactions (PPIs) is therefore an important inception step towards understanding the basics of c...

A new hyperbox selection rule and a pruning strategy for the enhanced fuzzy min-max neural network.

Neural networks : the official journal of the International Neural Network Society
In this paper, we extend our previous work on the Enhanced Fuzzy Min-Max (EFMM) neural network by introducing a new hyperbox selection rule and a pruning strategy to reduce network complexity and improve classification performance. Specifically, a ne...

Integrating network, sequence and functional features using machine learning approaches towards identification of novel Alzheimer genes.

BMC genomics
BACKGROUND: Alzheimer's disease (AD) is a complex progressive neurodegenerative disorder commonly characterized by short term memory loss. Presently no effective therapeutic treatments exist that can completely cure this disease. The cause of Alzheim...

TMSEG: Novel prediction of transmembrane helices.

Proteins
Transmembrane proteins (TMPs) are important drug targets because they are essential for signaling, regulation, and transport. Despite important breakthroughs, experimental structure determination remains challenging for TMPs. Various methods have bri...

Effect of Protein Repetitiveness on Protein-Protein Interaction Prediction Results Using Support Vector Machines.

Journal of computational biology : a journal of computational molecular cell biology
BACKGROUND: There are many computational approaches to predict the protein-protein interactions using support vector machines (SVMs) with high performance. In fact, performance of currently reported methods are significantly over-estimated and affect...

Predicting the Presence of Uncommon Elements in Unknown Biomolecules from Isotope Patterns.

Analytical chemistry
The determination of the molecular formula is one of the earliest and most important steps when investigating the chemical nature of an unknown compound. Common approaches use the isotopic pattern of a compound measured using mass spectrometry. Compu...

Longitudinal clinical score prediction in Alzheimer's disease with soft-split sparse regression based random forest.

Neurobiology of aging
Alzheimer's disease (AD) is an irreversible neurodegenerative disease and affects a large population in the world. Cognitive scores at multiple time points can be reliably used to evaluate the progression of the disease clinically. In recent studies,...

Machine learning, statistical learning and the future of biological research in psychiatry.

Psychological medicine
Psychiatric research has entered the age of 'Big Data'. Datasets now routinely involve thousands of heterogeneous variables, including clinical, neuroimaging, genomic, proteomic, transcriptomic and other 'omic' measures. The analysis of these dataset...

An Ensemble Approach for Cognitive Fault Detection and Isolation in Sensor Networks.

International journal of neural systems
Cognitive fault detection and diagnosis systems are systems able to provide timely information about possibly occurring faults without requiring any a priori knowledge about the process generating the data or the possible faults. This ability is cruc...