Understanding genetic mechanism of complex diseases is a serious challenge. Existing methods often neglect the heterogeneity phenomenon of complex diseases, resulting in lack of power or low reproducibility. Addressing heterogeneity when detecting ep...
IEEE journal of biomedical and health informatics
Apr 16, 2018
Compact binary representations of histopa-thology images using hashing methods provide efficient approximate nearest neighbor search for direct visual query in large-scale databases. They can be utilized to measure the probability of the abnormality ...
Journal of magnetic resonance imaging : JMRI
Apr 16, 2018
BACKGROUND: Deep learning is the most promising methodology for automatic computer-aided diagnosis of prostate cancer (PCa) with multiparametric MRI (mp-MRI).
The speed of super-resolution microscopy methods based on single-molecule localization, for example, PALM and STORM, is limited by the need to record many thousands of frames with a small number of observed molecules in each. Here, we present ANNA-PA...
BACKGROUND AND OBJECTIVE: Parkinson's disease (PD) is considered a degenerative disorder that affects the motor system, which may cause tremors, micrography, and the freezing of gait. Although PD is related to the lack of dopamine, the triggering pro...
RNA editing is a post-transcriptional RNA sequence alteration. Current methods have identified editing sites and facilitated research but require sufficient genomic annotations and prior-knowledge-based filtering steps, resulting in a cumbersome, tim...
IEEE/ACM transactions on computational biology and bioinformatics
Apr 16, 2018
With increased use of electronic medical records (EMRs), data mining on medical data has great potential to improve the quality of hospital treatment and increase the survival rate of patients. Early readmission prediction enables early intervention,...
Clinical Named Entity Recognition (NER) is a critical natural language processing (NLP) task to extract important concepts (named entities) from clinical narratives. Researchers have extensively investigated machine learning models for clinical NER. ...
Monitoring the future health status of patients from the historical Electronic Health Record (EHR) is a core research topic in predictive healthcare. The most important challenges are to model the temporality of sequential EHR data and to interpret t...
While biomedical ontologies have traditionally been used to guide the identification of concepts or relations in biomedical data, recent advances in deep learning are able to capture high-quality knowledge from textual data and represent it in graphi...
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