Cancer imaging : the official publication of the International Cancer Imaging Society
May 8, 2025
OBJECTIVE: Phyllodes tumors (PTs) are rare breast tumors with high recurrence rates, current methods relying on post-resection pathology often delay detection and require further surgery. We propose a deep-learning-based Phyllodes Tumors Hierarchical...
BACKGROUND AND OBJECTIVE: Accurate detection of schizophrenia poses a grand challenge as a complex and heterogeneous mental disorder. Current diagnostic criteria rely primarily on clinical symptoms, which may not fully capture individual differences ...
MOTIVATION: Molecular property prediction with deep learning has accelerated drug discovery and retrosynthesis. However, the shortage of labeled molecular data and the challenge of generalizing across the vast chemical spaces pose significant hurdles...
MOTIVATION: Understanding the protein sequence-function relationship is essential for advancing protein biology and engineering. However, <1% of known protein sequences have human-verified functions. While deep-learning methods have demonstrated prom...
MOTIVATION: Enhancers and promoters, as regulatory DNA elements, play pivotal roles in gene expression, homeostasis, and disease development across various biological processes. With advancing research, it has been uncovered that distal enhancers may...
In this issue of Developmental Cell, Yang et al. present an integrated experimental and computational platform that maps the spatiotemporal development of the human esophagus and predicts key signaling pathways governing epithelial differentiation. T...
Liquid-liquid phase separation plays a critical role in cellular processes, including protein aggregation and RNA metabolism, by forming membraneless subcellular structures. Accurate identification of phase-separated proteins is essential for underst...
Antibody-drug conjugates (ADCs) have revolutionized the field of cancer treatment in the era of precision medicine due to their ability to precisely target cancer cells and release highly effective drugs. Nevertheless, the rational design and discove...
During DNA transcription, the central dogma states that DNA generates corresponding RNA sequences based on the principle of complementary base pairing. However, in the allopolyploid line by goldfish and common carp hybrids, there is a significant lev...
Antibody-antigen interactions (AAIs) are a pervasive phenomenon in the natural and are instrumental in the design of antibody-based drugs. Despite the emergence of various deep learning-based methods aimed at enhancing the accuracy of AAIs prediction...
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