AIMC Topic: DNA Mismatch Repair

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MMRNet: Ensemble deep learning models for predicting mismatch repair deficiency in endometrial cancer from histopathological images.

Cell reports. Medicine May 20, 2025
Combining molecular classification with clinicopathologic methods improves risk assessment and chooses therapies for endometrial cancer (EC). Detecting mismatch repair (MMR) deficiencies in EC is crucial for screening Lynch syndrome and identifying i...
Humans Neural Networks, Computer Female Deep Learning ROC Curve DNA Mismatch Repair Endometrial Neoplasms Colorectal Neoplasms, Hereditary Nonpolyposis
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Artificial intelligence-driven microsatellite instability profiling reveals distinctive genetic features in patients with lung cancer.

Cancer May 1, 2025
BACKGROUND: Microsatellite instability (MSI) has emerged as a predictive biomarker for immunotherapy response in various cancers, but its role in non-small cell lung cancer (NSCLC) is not fully understood.
Humans Artificial Intelligence Retrospective Studies Female Aged Aged, 80 and over Adult Biomarkers, Tumor Male Middle Aged Lung Neoplasms Carcinoma, Non-Small-Cell Lung Microsatellite Instability DNA Mismatch Repair Mutation High-Throughput Nucleotide Sequencing
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Use of Deep Learning to Evaluate Tumor Microenvironmental Features for Prediction of Colon Cancer Recurrence.

Cancer research communications May 23, 2024
UNLABELLED: Deep learning may detect biologically important signals embedded in tumor morphologic features that confer distinct prognoses. Tumor morphologic features were quantified to enhance patient risk stratification within DNA mismatch repair (M...
Humans Prognosis Female Aged Tumor Microenvironment Male Middle Aged Deep Learning Antineoplastic Combined Chemotherapy Protocols DNA Mismatch Repair Neoplasm Recurrence, Local Colonic Neoplasms Fluorouracil Chemotherapy, Adjuvant Organoplatinum Compounds Leucovorin
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