AIMC Topic: DNA Mismatch Repair
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A radiogenomics study on F-FDG PET/CT in endometrial cancer by a novel deep learning segmentation algorithm.
BMC cancer
Jun 5, 2025
OBJECTIVE: To create an automated PET/CT segmentation method and radiomics model to forecast Mismatch repair (MMR) and TP53 gene expression in endometrial cancer patients, and to examine the effect of gene expression variability on image texture feat...
Artificial intelligence and whole slide imaging, a new tool for the microsatellite instability prediction in colorectal cancer: Friend or foe?
Critical reviews in oncology/hematology
Mar 8, 2025
Colorectal cancer (CRC) is the third most common and second most deadly cancer worldwide. Despite advances in screening and treatment, CRC is heterogeneous and the response to therapy varies significantly, limiting personalized treatment options. Cer...
Deep learning-assisted colonoscopy images for prediction of mismatch repair deficiency in colorectal cancer.
Surgical endoscopy
Dec 2, 2024
BACKGROUND: Deficient mismatch repair or microsatellite instability is a major predictive biomarker for the efficacy of immune checkpoint inhibitors of colorectal cancer. However, routine testing has not been uniformly implemented due to cost and res...
Classification of MLH1 Missense VUS Using Protein Structure-Based Deep Learning-Ramachandran Plot-Molecular Dynamics Simulations Method.
International journal of molecular sciences
Jan 10, 2024
Pathogenic variation in DNA mismatch repair (MMR) gene is associated with Lynch syndrome (LS), an autosomal dominant hereditary cancer. Of the 3798 germline variants collected in the ClinVar database, 38.7% (1469) were missense variants, of which 8...
Microsatellite Instability, Mismatch Repair, and Tumor Mutation Burden in Lung Cancer.
Surgical pathology clinics
Dec 20, 2023
Since US Food and Drug Administration approval of programmed death ligand 1 (PD-L1) as the first companion diagnostic for immune checkpoint inhibitors (ICIs) in non-small cell lung cancer, many patients have experienced increased overall survival. To...
CT-based deep learning model for the prediction of DNA mismatch repair deficient colorectal cancer: a diagnostic study.
Journal of translational medicine
Mar 22, 2023
BACKGROUND: Stratification of DNA mismatch repair (MMR) status in patients with colorectal cancer (CRC) enables individual clinical treatment decision making. The present study aimed to develop and validate a deep learning (DL) model based on the pre...
Clinical actionability of triaging DNA mismatch repair deficient colorectal cancer from biopsy samples using deep learning.
EBioMedicine
Jun 23, 2022
BACKGROUND: We aimed to develop a deep learning (DL) model to predict DNA mismatch repair (MMR) status in colorectal cancers (CRC) based on hematoxylin and eosin-stained whole-slide images (WSIs) and assess its clinical applicability.
Detecting immunotherapy-sensitive subtype in gastric cancer using histologic image-based deep learning.
Scientific reports
Nov 22, 2021
Immune checkpoint inhibitor (ICI) therapy is widely used but effective only in a subset of gastric cancers. Epstein-Barr virus (EBV)-positive and microsatellite instability (MSI) / mismatch repair deficient (dMMR) tumors have been reported to be high...
Humans
Herpesvirus 4, Human
Software
Area Under Curve
Neural Networks, Computer
DNA Mismatch Repair
Algorithms
Genome, Human
Databases, Factual
Microsatellite Instability
Deep Learning
Machine Learning
Immunohistochemistry
Reproducibility of Results
Stomach Neoplasms
Immunotherapy
Treatment Outcome
Lymphocytosis
Machine learning-based prediction of microsatellite instability and high tumor mutation burden from contrast-enhanced computed tomography in endometrial cancers.
Scientific reports
Oct 20, 2020
To evaluate whether radiomic features from contrast-enhanced computed tomography (CE-CT) can identify DNA mismatch repair deficient (MMR-D) and/or tumor mutational burden-high (TMB-H) endometrial cancers (ECs). Patients who underwent targeted massive...
DNA Polymerase II
Poly-ADP-Ribose Binding Proteins
Machine Learning
Computer Simulation
Prognosis
Tumor Suppressor Protein p53
Endometrial Neoplasms
Humans
Carcinoma, Endometrioid
Tomography, X-Ray Computed
Middle Aged
Microsatellite Instability
Uterus
Female
Cohort Studies
DNA Mismatch Repair
Neoplasm Staging
Aged
Mutation
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