Small (Weinheim an der Bergstrasse, Germany)
Nov 27, 2021
Atomic force microscopy (AFM) is one of the most popular imaging and characterizing methods applicable to a wide range of nanoscale material systems. However, high-resolution imaging using AFM generally suffers from a low scanning yield due to its me...
Forensic science international. Genetics
Nov 21, 2021
Machine learning obtains good accuracy in determining the number of contributors (NOC) in short tandem repeat (STR) mixture DNA profiles. However, the models used so far are not understandable to users as they only output a prediction without any rea...
DNase I hypersensitive sites (DHSs) is important for identifying the location of gene regulatory elements, such as promoters, enhancers, silencers, and so on. Thus, it is crucial for discriminating DHSs from non-DHSs. Although some traditional method...
The journal of physical chemistry letters
Oct 21, 2021
Diabatization of one-electron states in flexible molecular aggregates is a great challenge due to the presence of surface crossings between molecular orbital (MO) levels and the complex interaction between MOs of neighboring molecules. In this work, ...
Biochimica et biophysica acta. Gene regulatory mechanisms
Oct 18, 2021
To control gene transcription, DNA-binding transcription factors recognise specific sequence motifs in gene regulatory regions. A complete and reliable GO annotation of all DNA-binding transcription factors is key to investigating the delicate balanc...
Forensic science international. Genetics
Oct 13, 2021
DNA profiles are generated in forensic biology laboratories around the world. It is possible that these profiles are assessed by two independent people in order for the profiles to be 'read'. Recent work has been carried out to develop a neural netwo...
IEEE/ACM transactions on computational biology and bioinformatics
Oct 7, 2021
The rapid development of high-throughput sequencing technology provides unique opportunities for studying of transcription factor binding sites, but also brings new computational challenges. Recently, a series of discriminative motif discovery (DMD) ...
How noncoding DNA determines gene expression in different cell types is a major unsolved problem, and critical downstream applications in human genetics depend on improved solutions. Here, we report substantially improved gene expression prediction a...
As a key component of gene regulation, transcription factors (TFs) play an important role in a number of biological processes. To fully understand the underlying mechanism of TF-mediated gene regulation, it is therefore critical to accurately identif...
Protein-DNA interactions play an important role in biological progress, such as DNA replication, repair, and modification processes. In order to have a better understanding of its functions, the one of the most important steps is the identification o...
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