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Drug Development

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AI-based language models powering drug discovery and development.

Drug discovery today
The discovery and development of new medicines is expensive, time-consuming, and often inefficient, with many failures along the way. Powered by artificial intelligence (AI), language models (LMs) have changed the landscape of natural language proces...

Convolutional neural networks (CNNs): concepts and applications in pharmacogenomics.

Molecular diversity
Convolutional neural networks (CNNs) have been used to extract information from various datasets of different dimensions. This approach has led to accurate interpretations in several subfields of biological research, like pharmacogenomics, addressing...

Machine learning directed drug formulation development.

Advanced drug delivery reviews
Machine learning (ML) has enabled ground-breaking advances in the healthcare and pharmaceutical sectors, from improvements in cancer diagnosis, to the identification of novel drugs and drug targets as well as protein structure prediction. Drug formul...

Harnessing artificial intelligence for the next generation of 3D printed medicines.

Advanced drug delivery reviews
Artificial intelligence (AI) is redefining how we exist in the world. In almost every sector of society, AI is performing tasks with super-human speed and intellect; from the prediction of stock market trends to driverless vehicles, diagnosis of dise...

Application of Machine Learning in Translational Medicine: Current Status and Future Opportunities.

The AAPS journal
The exponential increase in our ability to harness multi-dimensional biological and clinical data from experimental to real-world settings has transformed pharmaceutical research and development in recent years, with increasing applications of artifi...

Big Techs and startups in pharmaceutical R&D - A 2020 perspective on artificial intelligence.

Drug discovery today
We investigated what kind of artificial intelligence (AI) technologies are utilized in pharmaceutical research and development (R&D) and which sources of AI-related competencies can be leveraged by pharmaceutical companies. First, we found that machi...

Utilizing Artificial Intelligence to Manage COVID-19 Scientific Evidence Torrent with Risklick AI: A Critical Tool for Pharmacology and Therapy Development.

Pharmacology
INTRODUCTION: The SARS-CoV-2 pandemic has led to one of the most critical and boundless waves of publications in the history of modern science. The necessity to find and pursue relevant information and quantify its quality is broadly acknowledged. Mo...

AutoDTI++: deep unsupervised learning for DTI prediction by autoencoders.

BMC bioinformatics
BACKGROUND: Drug-target interaction (DTI) plays a vital role in drug discovery. Identifying drug-target interactions related to wet-lab experiments are costly, laborious, and time-consuming. Therefore, computational methods to predict drug-target int...

Artificial intelligence to deep learning: machine intelligence approach for drug discovery.

Molecular diversity
Drug designing and development is an important area of research for pharmaceutical companies and chemical scientists. However, low efficacy, off-target delivery, time consumption, and high cost impose a hurdle and challenges that impact drug design a...

GanDTI: A multi-task neural network for drug-target interaction prediction.

Computational biology and chemistry
Drug discovery processes require drug-target interaction (DTI) prediction by virtual screenings with high accuracy. Compared with traditional methods, the deep learning method requires less time and domain expertise, while achieving higher accuracy. ...