AIMC Topic: Epitopes, T-Lymphocyte

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Introducing of an integrated artificial neural network and Chou's pseudo amino acid composition approach for computational epitope-mapping of Crimean-Congo haemorrhagic fever virus antigens.

International immunopharmacology Nov 24, 2019
This study was aimed to introduce a novel algorithm for determining linear B- and T-cell epitopes from Crimean-Congo haemorrhagic fever virus (CCHFV) antigens. To this end, 387 approved B- and T-cell epitopes, as well as 331 non-epitope peptides from...
Histocompatibility Antigens Class II Epitopes, B-Lymphocyte Epitope Mapping Viral Proteins Antigens, Viral Protein Structure, Tertiary Hemorrhagic Fever Virus, Crimean-Congo Hemorrhagic Fever, Crimean Epitopes, T-Lymphocyte Molecular Docking Simulation Peptide Library Amino Acid Sequence Datasets as Topic Computational Biology Support Vector Machine Humans Neural Networks, Computer
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DeepHLApan: A Deep Learning Approach for Neoantigen Prediction Considering Both HLA-Peptide Binding and Immunogenicity.

Frontiers in immunology Nov 1, 2019
Neoantigens play important roles in cancer immunotherapy. Current methods used for neoantigen prediction focus on the binding between human leukocyte antigens (HLAs) and peptides, which is insufficient for high-confidence neoantigen prediction. In th...
HLA Antigens Humans Antigens, Neoplasm Neoplasms CD8-Positive T-Lymphocytes Peptides Epitopes, T-Lymphocyte Mutation Deep Learning
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Machine-Learning Prediction of Tumor Antigen Immunogenicity in the Selection of Therapeutic Epitopes.

Cancer immunology research Sep 12, 2019
Current tumor neoantigen calling algorithms primarily rely on epitope/major histocompatibility complex (MHC) binding affinity predictions to rank and select for potential epitope targets. These algorithms do not predict for epitope immunogenicity usi...
Humans T-Lymphocytes, Cytotoxic Peptide Fragments Histocompatibility Antigens Class I Epitopes, T-Lymphocyte Histocompatibility Antigens Class II Mice Computational Biology Animals Machine Learning Mice, Inbred BALB C Cancer Vaccines Algorithms Mice, Inbred C57BL Male Antigens, Neoplasm Female Neoplasms
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Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides.

Journal for immunotherapy of cancer May 22, 2019
BACKGROUND: Targeting epitopes derived from neo-antigens (or "neo-epitopes") represents a promising immunotherapy approach with limited off-target effects. However, most peptides predicted using MHC binding prediction algorithms do not induce a CD8 +...
Epitopes, T-Lymphocyte Lymphocyte Activation Protein Binding Oligopeptides Immunotherapy Mutation Humans Machine Learning
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Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space.

Frontiers in immunology Apr 16, 2019
Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different...
Immunodominant Epitopes Thermodynamics Major Histocompatibility Complex Antigen Presentation Humans Machine Learning Receptors, Antigen, T-Cell Datasets as Topic Computer Simulation Computational Biology Adaptive Immunity T-Lymphocytes Epitopes, T-Lymphocyte
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Pan-Specific Prediction of Peptide-MHC Class I Complex Stability, a Correlate of T Cell Immunogenicity.

Journal of immunology (Baltimore, Md. : 1950) Jul 8, 2016
Binding of peptides to MHC class I (MHC-I) molecules is the most selective event in the processing and presentation of Ags to CTL, and insights into the mechanisms that govern peptide-MHC-I binding should facilitate our understanding of CTL biology. ...
Protein Stability Antigen Presentation Peptides Lymphocyte Activation Humans Histocompatibility Antigens Class I Neural Networks, Computer Epitopes, T-Lymphocyte
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Phage display enables machine learning discovery of cancer antigen-specific TCRs.

Science advances Jun 13, 2025
T cells targeting epitopes in infectious diseases or cancer play a central role in spontaneous and therapy-induced immune responses. Epitope recognition is mediated by the binding of the T cell receptor (TCR), and TCRs recognizing clinically relevant...
Humans Machine Learning Peptide Library Antigens, Neoplasm Neoplasms Membrane Proteins Epitopes, T-Lymphocyte Cell Surface Display Techniques Receptors, Antigen, T-Cell
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An Integrated Approach to Develop a Potent Vaccine Candidate Construct Against Prostate Cancer by Utilizing Machine Learning and Bioinformatics.

Cancer reports (Hoboken, N.J.) Dec 1, 2024
BACKGROUND: Prostate cancer is the most common malignancy among males. Prostaglandin G/H synthase (PGHS) is an essential enzyme in the synthesis of prostaglandins, and its activation has been linked to many malignancies, including colorectal cancer.
Epitopes, B-Lymphocyte Vaccines, Subunit Vaccine Development Prostatic Neoplasms Molecular Dynamics Simulation Humans Machine Learning Male Computational Biology Cancer Vaccines Epitopes, T-Lymphocyte Molecular Docking Simulation
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HLAIImaster: a deep learning method with adaptive domain knowledge predicts HLA II neoepitope immunogenic responses.

Briefings in bioinformatics May 23, 2024
While significant strides have been made in predicting neoepitopes that trigger autologous CD4+ T cell responses, accurately identifying the antigen presentation by human leukocyte antigen (HLA) class II molecules remains a challenge. This identifica...
Computational Biology Humans Epitopes Epitopes, T-Lymphocyte Histocompatibility Antigens Class II Deep Learning
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TEPCAM: Prediction of T-cell receptor-epitope binding specificity via interpretable deep learning.

Protein science : a publication of the Protein Society Jan 1, 2024
The recognition of T-cell receptor (TCR) on the surface of T cell to specific epitope presented by the major histocompatibility complex is the key to trigger the immune response. Identifying the binding rules of TCR-epitope pair is crucial for develo...
Epitopes, T-Lymphocyte Deep Learning Receptors, Antigen, T-Cell Protein Binding T-Lymphocytes
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