AIMC Topic: Estrogen Receptor alpha

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Predicting estrogen receptor agonists from plastic additives across various aquatic-related species using machine learning and AlphaFold2.

Journal of hazardous materials Aug 15, 2025
The absence of effective public databases greatly limits high-throughput prediction of hormonal effects mediated by nuclear receptors in aquatic organisms. In this study, we developed novel strategies for multi-species screening of estrogen receptor ...
Neural Networks, Computer Machine Learning Animals Water Pollutants, Chemical Aquatic Organisms Receptors, Estrogen Estrogen Receptor alpha
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Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations.

Genome biology May 9, 2025
BACKGROUND: The incidence and mortality of endometrial cancer (EC) is on the rise. Eighty-five percent of ECs depend on estrogen receptor alpha (ERĪ±) for proliferation, but little is known about its transcriptional regulation in these tumors.
Humans Female Polymorphism, Single Nucleotide Epigenesis, Genetic Gene Expression Regulation, Neoplastic Carcinogenesis Mutation Genome, Human Endometrial Neoplasms Estrogen Receptor alpha Enhancer Elements, Genetic
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