AIMC Topic: Estrogen Receptor alpha

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Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding.

Journal of medicinal chemistry Jun 11, 2020
DNA-encoded small molecule libraries (DELs) have enabled discovery of novel inhibitors for many distinct protein targets of therapeutic value. We demonstrate a new approach applying machine learning to DEL selection data by identifying active molecul...
Neural Networks, Computer Small Molecule Libraries Drug Discovery Proto-Oncogene Proteins c-kit Estrogen Receptor alpha DNA Epoxide Hydrolases Ligands Protein Kinase Inhibitors
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Analysis of the Deleterious Single Nucleotide Polymorphisms Impact on Estrogen Receptor Alpha-p53 Interaction: A Machine Learning Approach.

International journal of molecular sciences Jun 18, 2019
Breast cancer is a leading cancer type and one of the major health issues faced by women around the world. Some of its major risk factors include body mass index, hormone replacement therapy, family history and germline mutations. Of these risk facto...
Humans Neural Networks, Computer Molecular Dynamics Simulation Tumor Suppressor Protein p53 Protein Conformation Estrogen Receptor alpha Protein Interaction Domains and Motifs Polymorphism, Single Nucleotide Computational Biology Structure-Activity Relationship Mutation Machine Learning Molecular Docking Simulation Protein Binding
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Machine learning identifies interacting genetic variants contributing to breast cancer risk: A case study in Finnish cases and controls.

Scientific reports Sep 3, 2018
We propose an effective machine learning approach to identify group of interacting single nucleotide polymorphisms (SNPs), which contribute most to the breast cancer (BC) risk by assuming dependencies among BCAC iCOGS SNPs. We adopt a gradient tree b...
Humans Gene Expression Regulation, Neoplastic Support Vector Machine Prognosis Base Sequence Case-Control Studies Genome, Human Genome-Wide Association Study Gene Regulatory Networks Genetic Predisposition to Disease Polymorphism, Single Nucleotide Protein Interaction Mapping Estrogen Receptor alpha Risk Ubiquitin-Protein Ligases Finland Female Breast Neoplasms
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Convolutional Neural Network Using a Breast MRI Tumor Dataset Can Predict Oncotype Dx Recurrence Score.

Journal of magnetic resonance imaging : JMRI Aug 21, 2018
BACKGROUND: Oncotype Dx is a validated genetic analysis that provides a recurrence score (RS) to quantitatively predict outcomes in patients who meet the criteria of estrogen receptor positive / human epidermal growth factor receptor-2 negative (ER+/...
Estrogen Receptor alpha Area Under Curve Neoplasm Recurrence, Local Receptor, ErbB-2 Carcinoma, Ductal, Breast Image Processing, Computer-Assisted Treatment Outcome Magnetic Resonance Imaging Reproducibility of Results Aged Adult ROC Curve Imaging, Three-Dimensional Breast Neoplasms Middle Aged Neural Networks, Computer Algorithms Humans Retrospective Studies Female
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Insight Analysis of Promiscuous Estrogen Receptor α-Ligand Binding by a Novel Machine Learning Scheme.

Chemical research in toxicology Jul 30, 2018
Estrogen receptor α (ERα) plays a significant role in occurrence of breast cancer and may cause various adverse side-effects when ERα is an off-target protein. A theoretical model was derived to predict the binding affinity of ERα using the pharmacop...
Reproducibility of Results Protein Binding Support Vector Machine Quantitative Structure-Activity Relationship Crystallography, X-Ray Models, Molecular Ligands Humans Machine Learning Computer Simulation Protein Conformation Estrogen Receptor alpha
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Support vector machine for breast cancer classification using diffusion-weighted MRI histogram features: Preliminary study.

Journal of magnetic resonance imaging : JMRI Oct 16, 2017
BACKGROUND: Diffusion-weighted MRI (DWI) is currently one of the fastest developing MRI-based techniques in oncology. Histogram properties from model fitting of DWI are useful features for differentiation of lesions, and classification can potentiall...
Echo-Planar Imaging Receptor, ErbB-2 Estrogen Receptor alpha Diffusion Magnetic Resonance Imaging Reproducibility of Results Aged Adult Breast Neoplasms Algorithms Prospective Studies Female Breast Diffusion Humans Motion Machine Learning Image Interpretation, Computer-Assisted Middle Aged Image Processing, Computer-Assisted Support Vector Machine
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Predicting estrogen receptor agonists from plastic additives across various aquatic-related species using machine learning and AlphaFold2.

Journal of hazardous materials Aug 15, 2025
The absence of effective public databases greatly limits high-throughput prediction of hormonal effects mediated by nuclear receptors in aquatic organisms. In this study, we developed novel strategies for multi-species screening of estrogen receptor ...
Water Pollutants, Chemical Aquatic Organisms Receptors, Estrogen Estrogen Receptor alpha Neural Networks, Computer Machine Learning Animals
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Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations.

Genome biology May 9, 2025
BACKGROUND: The incidence and mortality of endometrial cancer (EC) is on the rise. Eighty-five percent of ECs depend on estrogen receptor alpha (ERα) for proliferation, but little is known about its transcriptional regulation in these tumors.
Mutation Epigenesis, Genetic Genome, Human Gene Expression Regulation, Neoplastic Endometrial Neoplasms Carcinogenesis Estrogen Receptor alpha Humans Enhancer Elements, Genetic Female Polymorphism, Single Nucleotide
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