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Gene Ontology

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Extending the evaluation of Genia Event task toward knowledge base construction and comparison to Gene Regulation Ontology task.

BMC bioinformatics
BACKGROUND: The third edition of the BioNLP Shared Task was held with the grand theme "knowledge base construction (KB)". The Genia Event (GE) task was re-designed and implemented in light of this theme. For its final report, the participating system...

Application of comparative biology in GO functional annotation: the mouse model.

Mammalian genome : official journal of the International Mammalian Genome Society
The Gene Ontology (GO) is an important component of modern biological knowledge representation with great utility for computational analysis of genomic and genetic data. The Gene Ontology Consortium (GOC) consists of a large team of contributors incl...

A tuberculosis ontology for host systems biology.

Tuberculosis (Edinburgh, Scotland)
A major hurdle facing tuberculosis (TB) investigators who want to utilize a rapidly growing body of data from both systems biology approaches and omics technologies is the lack of a standard vocabulary for data annotation and reporting. Lacking a mea...

The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease.

American journal of human genetics
The Human Phenotype Ontology (HPO) is widely used in the rare disease community for differential diagnostics, phenotype-driven analysis of next-generation sequence-variation data, and translational research, but a comparable resource has not been ava...

Pre_GI: a global map of ontological links between horizontally transferred genomic islands in bacterial and archaeal genomes.

Database : the journal of biological databases and curation
The Predicted Genomic Islands database (Pre_GI) is a comprehensive repository of prokaryotic genomic islands (islands, GIs) freely accessible at http://pregi.bi.up.ac.za/index.php. Pre_GI, Version 2015, catalogues 26 744 islands identified in 2407 ba...

Systems analysis of gene ontology and biological pathways involved in post-myocardial infarction responses.

BMC genomics
BACKGROUND: Pathway analysis has been widely used to gain insight into essential mechanisms of the response to myocardial infarction (MI). Currently, there exist multiple pathway databases that organize molecular datasets and manually curate pathway ...

Gene Ontology and KEGG Pathway Enrichment Analysis of a Drug Target-Based Classification System.

PloS one
Drug-target interaction (DTI) is a key aspect in pharmaceutical research. With the ever-increasing new drug data resources, computational approaches have emerged as powerful and labor-saving tools in predicting new DTIs. However, so far, most of thes...

Computational algorithms to predict Gene Ontology annotations.

BMC bioinformatics
BACKGROUND: Gene function annotations, which are associations between a gene and a term of a controlled vocabulary describing gene functional features, are of paramount importance in modern biology. Datasets of these annotations, such as the ones pro...