AIMC Topic: Glioma

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Interpreting deep learning models for glioma survival classification using visualization and textual explanations.

BMC medical informatics and decision making
BACKGROUND: Saliency-based algorithms are able to explain the relationship between input image pixels and deep-learning model predictions. However, it may be difficult to assess the clinical value of the most important image features and the model pr...

Neuropathologist-level integrated classification of adult-type diffuse gliomas using deep learning from whole-slide pathological images.

Nature communications
Current diagnosis of glioma types requires combining both histological features and molecular characteristics, which is an expensive and time-consuming procedure. Determining the tumor types directly from whole-slide images (WSIs) is of great value f...

TumorDetNet: A unified deep learning model for brain tumor detection and classification.

PloS one
Accurate diagnosis of the brain tumor type at an earlier stage is crucial for the treatment process and helps to save the lives of a large number of people worldwide. Because they are non-invasive and spare patients from having an unpleasant biopsy, ...

Tumor Mutation Burden-Related Histopathologic Features for Predicting Overall Survival in Gliomas Using Graph Deep Learning.

The American journal of pathology
Tumor mutation burden (TMB) is a potential biomarker for evaluating the prognosis and response to immune checkpoint inhibitors, but its costly and time-consuming method of measurement limits its widespread application. This study aimed to identify th...

Noninvasive grading of glioma brain tumors using magnetic resonance imaging and deep learning methods.

Journal of cancer research and clinical oncology
PURPOSE: Convolutional Neural Networks (ConvNets) have quickly become popular machine learning techniques in recent years, particularly in the classification and segmentation of medical images. One of the most prevalent types of brain cancers is glio...

Natural language processing deep learning models for the differential between high-grade gliomas and metastasis: what if the key is how we report them?

European radiology
OBJECTIVES: The differential between high-grade glioma (HGG) and metastasis remains challenging in common radiological practice. We compare different natural language processing (NLP)-based deep learning models to assist radiologists based on data co...

Deep learning based on dynamic susceptibility contrast MR imaging for prediction of local progression in adult-type diffuse glioma (grade 4).

Scientific reports
Adult-type diffuse glioma (grade 4) has infiltrating nature, and therefore local progression is likely to occur within surrounding non-enhancing T2 hyperintense areas even after gross total resection of contrast-enhancing lesions. Cerebral blood volu...

A novel MRI-based deep learning networks combined with attention mechanism for predicting CDKN2A/B homozygous deletion status in IDH-mutant astrocytoma.

European radiology
OBJECTIVES: To develop a high-accuracy MRI-based deep learning method for predicting cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) homozygous deletion status in isocitrate dehydrogenase (IDH)-mutant astrocytoma.

Cuproptosis facilitates immune activation but promotes immune escape, and a machine learning-based cuproptosis-related signature is identified for predicting prognosis and immunotherapy response of gliomas.

CNS neuroscience & therapeutics
AIMS: Cell death, except for cuproptosis, in gliomas has been extensively studied, providing novel targets for immunotherapy by reshaping the tumor immune microenvironment through multiple mechanisms. This study aimed to explore the effect of cupropt...