AIMC Topic: Glycosylation

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The Major Chromophore Arising from Glucose Degradation and Oxidative Stress Occurrence during Lens Proteins Glycation Induced by Glucose.

Molecules (Basel, Switzerland) Dec 22, 2017
Glucose autoxidation has been proposed as a key reaction associated with deleterious effects induced by hyperglycemia in the eye lens. Little is known about chromophores generated during glucose autoxidation. In this study, we analyzed the effect of ...
Crystallins Lens, Crystalline Gluconates Copper Pyruvaldehyde Oxidative Stress Glucose Glycosylation Solutions Oxidation-Reduction Cations, Divalent Animals Hydrogen Peroxide Cattle Glyoxal Lysine
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Glypre: In Silico Prediction of Protein Glycation Sites by Fusing Multiple Features and Support Vector Machine.

Molecules (Basel, Switzerland) Nov 3, 2017
Glycation is a non-enzymatic process occurring inside or outside the host body by attaching a sugar molecule to a protein or lipid molecule. It is an important form of post-translational modification (PTM), which impairs the function and changes the ...
Algorithms Computer Simulation Sensitivity and Specificity Lysine Binding Sites ROC Curve Proteins Glycosylation Area Under Curve Support Vector Machine Amino Acids
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Predicting lysine glycation sites using bi-profile bayes feature extraction.

Computational biology and chemistry Oct 12, 2017
Glycation is a nonenzymatic post-translational modification which has been found to be involved in various biological processes and closely associated with many metabolic diseases. The accurate identification of glycation sites is important to unders...
Computational Biology Glycosylation Lysine Support Vector Machine Bayes Theorem Internet
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Factors analysis of protein O-glycosylation site prediction.

Computational biology and chemistry Sep 18, 2017
To improve the prediction accuracy of O-glycosylation sites, and analyze the structure of the O-glycosylation sites, factor analysis based prediction is proposed in this study. Our studies show that factor analysis strongly boosts machine learning al...
Principal Component Analysis Discriminant Analysis Glycosylation Proteins Databases, Protein Machine Learning Algorithms
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Prediction of N-linked glycosylation sites using position relative features and statistical moments.

PloS one Aug 10, 2017
Glycosylation is one of the most complex post translation modification in eukaryotic cells. Almost 50% of the human proteome is glycosylated as glycosylation plays a vital role in various biological functions such as antigen's recognition, cell-cell ...
Glycosylation Support Vector Machine Databases, Protein Amino Acid Sequence Sequence Analysis, Protein Neural Networks, Computer Algorithms Computational Biology Humans
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A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts.

PLoS computational biology Apr 7, 2016
O-linked glycosylation is an important post-translational modification of mucin-type protein, changes to which are important biomarkers of cancer. For this study of the enzymes of O-glycosylation, we developed a shorthand notation for representing Ga...
Glycosyltransferases Genetic Engineering Humans Metabolic Networks and Pathways Models, Biological Glycosylation Polysaccharides Protein Processing, Post-Translational Terminology as Topic Computer Simulation CHO Cells Knowledge Bases Gene Knockout Techniques Mucins Cricetulus Animals Computational Biology
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A two-layered machine learning method to identify protein O-GlcNAcylation sites with O-GlcNAc transferase substrate motifs.

BMC bioinformatics Dec 9, 2015
Protein O-GlcNAcylation, involving the β-attachment of single N-acetylglucosamine (GlcNAc) to the hydroxyl group of serine or threonine residues, is an O-linked glycosylation catalyzed by O-GlcNAc transferase (OGT). Molecular level investigation of t...
Substrate Specificity Amino Acid Motifs N-Acetylglucosaminyltransferases Machine Learning Algorithms Mass Spectrometry Peptides Acetylglucosamine Proteins User-Computer Interface Internet Glycosylation Support Vector Machine
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GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome.

Bioinformatics (Oxford, England) Jan 6, 2015
MOTIVATION: Glycosylation is a ubiquitous type of protein post-translational modification (PTM) in eukaryotic cells, which plays vital roles in various biological processes (BPs) such as cellular communication, ligand recognition and subcellular reco...
Algorithms Proteome Glycosylation Sequence Analysis, Protein Protein Processing, Post-Translational Amino Acids Humans Artificial Intelligence Software
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The Construction of a New Prognostic Model of Breast Cancer and the Exploration of Drug Sensitivity Based on Machine Learning for Glycosylation-Related Genes.

Clinical breast cancer Aug 1, 2025
AIMS: Breast cancer has become the number 1 killer threatening women's health. In recent years, glycosylation modification has played an increasingly important role in tumor progression. The aim of this study was to explore the key genes that may be ...
Prognosis Female Breast Neoplasms Biomarkers, Tumor Humans Machine Learning Protein Interaction Maps Molecular Docking Simulation Gene Expression Regulation, Neoplastic Glycosylation Antineoplastic Agents Drug Resistance, Neoplasm Gene Expression Profiling
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Glycosyltransferases in human milk oligosaccharide synthesis: structural mechanisms and rational design.

Current opinion in biotechnology Jun 1, 2025
Human milk oligosaccharides (HMOs) play a pivotal role in infant health through their multifunctional bioactive properties. Recent advances in synthetic biology have revolutionized microbial platforms for HMO biosynthesis, with glycosyltransferases (...
Glycosyltransferases Humans Oligosaccharides Milk, Human Protein Engineering Glycosylation
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