AIMC Topic: Hippocampus

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Hippocampal representations for deep learning on Alzheimer's disease.

Scientific reports
Deep learning offers a powerful approach for analyzing hippocampal changes in Alzheimer's disease (AD) without relying on handcrafted features. Nevertheless, an input format needs to be selected to pass the image information to the neural network, wh...

Normalized unitary synaptic signaling of the hippocampus and entorhinal cortex predicted by deep learning of experimental recordings.

Communications biology
Biologically realistic computer simulations of neuronal circuits require systematic data-driven modeling of neuron type-specific synaptic activity. However, limited experimental yield, heterogeneous recordings conditions, and ambiguous neuronal ident...

Hippocampal formation-inspired probabilistic generative model.

Neural networks : the official journal of the International Neural Network Society
In building artificial intelligence (AI) agents, referring to how brains function in real environments can accelerate development by reducing the design space. In this study, we propose a probabilistic generative model (PGM) for navigation in uncerta...

The impact of transfer learning on 3D deep learning convolutional neural network segmentation of the hippocampus in mild cognitive impairment and Alzheimer disease subjects.

Human brain mapping
Research on segmentation of the hippocampus in magnetic resonance images through deep learning convolutional neural networks (CNNs) shows promising results, suggesting that these methods can identify small structural abnormalities of the hippocampus,...

Toward the biological model of the hippocampus as the successor representation agent.

Bio Systems
The hippocampus is an essential brain region for spatial memory and learning. Recently, a theoretical model of the hippocampus based on temporal difference (TD) learning has been published. Inspired by the successor representation (SR) learning algor...

Learning Cognitive Map Representations for Navigation by Sensory-Motor Integration.

IEEE transactions on cybernetics
How to transform a mixed flow of sensory and motor information into memory state of self-location and to build map representations of the environment are central questions in the navigation research. Studies in neuroscience have shown that place cell...

Deep learning and radiomics based automatic diagnosis of hippocampal sclerosis.

The International journal of neuroscience
Accurate and rapid segmentation of the hippocampus can help doctors perform intractable temporal lobe epilepsy (TLE) preoperative evaluations to identify good surgical candidates. This study aims to establish a radiomics system for the automatic diag...

Deep learning-based diagnosis of temporal lobe epilepsy associated with hippocampal sclerosis: An MRI study.

Epilepsy research
PURPOSE: The currently available indicators-sensitivity and specificity of expert radiological evaluation of MRIs-to identify mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) are deficient, as they cannot be easily asse...

Identification of Alzheimer associated differentially expressed gene through microarray data and transfer learning-based image analysis.

Neuroscience letters
Major factors contribute to mental stress and enhance the progression of late-onset Alzheimer's disease (AD). The factors that lead to neurodegeneration, such as tau protein hyperphosphorylation and increased amyloid-beta production, can be mimicked ...

MRI-Based Machine Learning Prediction Framework to Lateralize Hippocampal Sclerosis in Patients With Temporal Lobe Epilepsy.

Neurology
BACKGROUND AND OBJECTIVES: MRI fails to reveal hippocampal pathology in 30% to 50% of temporal lobe epilepsy (TLE) surgical candidates. To address this clinical challenge, we developed an automated MRI-based classifier that lateralizes the side of co...