AIMC Topic: Humans

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Extrachromosomal circular DNA drives dynamic genome plasticity: emerging roles in disease progression and clinical potential.

Theranostics
Extrachromosomal circular DNA (eccDNA) has emerged as a dynamic and versatile genomic element with key roles in physiological regulation and disease pathology. This review synthesizes current knowledge on eccDNA, covering its classification, biogenes...

Reshaping Organizational Culture in Pathology.

Clinics in laboratory medicine
"Reshaping Pathology Culture" explores the transformation needed in pathology departments to meet the demands of modern health care. It advocates a shift from traditional hierarchical models to collaborative leadership, uniting cross-generational pat...

Task-specific differentiation of patellofemoral pain in women using a neural network analysis of joint angle subsets.

Gait & posture
BACKGROUND: Individuals with patellofemoral pain (PFP) present mechanical disorders during functional tests and activities. Studies often evaluate this population to understand the relationship between mechanical factors and pain/malalignment. This s...

Novel Computational Approaches in the Discovery and Identification of Bioactive Peptides: A Bioinformatics Perspective.

Journal of agricultural and food chemistry
Bioactive peptides are protein molecules known for their specific biological functions, offering promising applications across various fields including medicine, food, and cosmetics. Traditional approaches to the investigation of bioactive peptides t...

Novel Antimicrobials from Computational Modelling and Drug Repositioning: Potential Strategies to Increase Therapeutic Arsenal Against Antimicrobial Resistance.

Molecules (Basel, Switzerland)
Antimicrobial resistance (AMR) is one of the most significant public health threats today. The need for new antimicrobials against multidrug-resistant infections is growing. The development of computational models capable of predicting new drug-targe...

The two ends of the spectrum: comparing chronic schizophrenia and premorbid latent schizotypy by actigraphy.

BMC psychiatry
Motor activity alterations are key symptoms of psychiatric disorders like schizophrenia. Actigraphy, a non-invasive monitoring method, shows promise in early identification. This study characterizes Positive Schizotypy Factor (PSF) and Chronic Schizo...

Mobile applications for skin cancer detection are vulnerable to physical camera-based adversarial attacks.

Scientific reports
Skin cancer is one of the most prevalent malignant tumors, and early detection is crucial for patient prognosis, leading to the development of mobile applications as screening tools. Recent advances in deep neural networks (DNNs) have accelerated the...

Image guided construction of a common coordinate framework for spatial transcriptome data.

Scientific reports
Spatial transcriptomics is a powerful technology for high-resolution mapping of gene expression in tissue samples, enabling a molecular level understanding of tissue architecture. The acquisition entails dissecting and profiling micron-thick tissue s...

A Comprehensive Video Dataset for Surgical Laparoscopic Action Analysis.

Scientific data
Laparoscopic surgery has been widely used in various surgical fields due to its minimally invasive and rapid recovery benefits. However, it demands a high level of technical expertise from surgeons. While advancements in computer vision and deep lear...

Exploring voice as a digital phenotype in adults with ADHD.

Scientific reports
Current diagnostic procedures for attention deficit hyperactivity disorder (ADHD) are mainly subjective and prone to bias. While research on potential biomarkers, including EEG, brain imaging, and genetics is promising, it has yet to demonstrate clin...