AIMC Topic: Erythropoietin

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Deep generative models design mRNA sequences with enhanced translational capacity and stability.

Science (New York, N.Y.)
Despite the success of messenger RNA (mRNA) COVID-19 vaccines, extending this modality to more diseases necessitates substantial enhancements. We present GEMORNA, a generative RNA model that uses transformer architectures tailored for mRNA coding seq...

Transcriptomic Biomarkers in Blood Indicative of the Administration of Recombinant Human Erythropoietin to Thoroughbred Horses.

Drug testing and analysis
Erythropoiesis-stimulating agents (ESAs) continue to be a significant threat to the integrity of human and equine sports. Besides conventional direct testing, monitoring the biomarkers associated with the effects of ESAs may provide a complementary a...

Peri-operative blood management of Jehovah's Witnesses undergoing cytoreductive surgery for advanced ovarian cancer.

Blood transfusion = Trasfusione del sangue
BACKGROUND: The aim of this study was to evaluate the efficacy and feasibility of a peri-operative bloodless medicine and surgery (BMS) protocol in reducing severe post-operative anaemia (haemoglobin [Hb] <7 g/dL) in Jehovah's Witnesses undergoing cy...

Hip Fracture Surgery without Transfusion in Patients with Hemoglobin Less Than 10 g/dL.

Clinics in orthopedic surgery
BACKGROUD: Hip fracture surgery is associated with blood loss, which may lead to adverse patient outcomes. The hemoglobin level declines gradually in most hip fracture cases involving femoral neck fractures and intertrochanteric fractures. It decreas...

Regular cold water swimming during winter time affects resting hematological parameters and serum erythropoietin.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Recreational winter swimming in cold sea water evokes body responses to regularly repeated cold water immersion. However, the understanding of adaptive changes is still limited and data regarding very short-term exposure to severe cold stress are sca...

Machine Learning Classifier Using Blood Count Parameters and Erythropoietin to Predict JAK2 Mutations in Patients With Erythrocytosis.

Archives of pathology & laboratory medicine
CONTEXT.—: Differentiating polycythemia vera from other causes of erythrocytosis is a diagnostic challenge. Although most patients with polycythemia vera have Janus kinase 2 (JAK2) mutations, extensive testing is impractical because this is an uncomm...

Can polycythaemia vera disease be predicted from haematologic parameters? A machine learning-based study.

Journal of clinical pathology
AIMS: The aim of this research is to diagnose polycythaemia vera (PV) disease using different machine learning (ML) algorithms with complete blood count (CBC) parameters before further investigations such as Janus kinase 2 (), erythropoietin (EPO) an...

Learning Enabled Control for Optimal EPO Dosage in Virtual CKD Patients: Case of Bleeding and Missing Dosage.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Traditional model-based control methods require predictive models to design control policies. These models often suffer limitations on dimensionality, uncertainty, and unmodeled dynamics. This affects the performance of control policy, especially, pe...

Diagnosis and Management of Polycythemia Vera in a Ferret ().

Comparative medicine
A 5-y-old female ferret (Mustela putorius furo) was evaluated for diarrhea, anorexia, and lethargy for 1 wk. Only mild dehydration was detected on physical examination. CBC analysis revealed marked erythrocytosis with an unremarkable plasma biochemis...

[Protective effect of erythropoietin on brain tissue in rats with cardiopulmonary resuscitation after asphyxia].

Zhonghua wei zhong bing ji jiu yi xue
OBJECTIVE: To study the protective effect of erythropoietin (EPO) on brain tissue with cardiac arrest-cardiopulmonary resuscitation (CA-CPR) and its mechanism.