AIMC Topic: Knowledge Bases
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Contrasting Multi-Source Temporal Knowledge Graphs for Biomedical Hypothesis Generation.
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Hypothesis Generation (HG) aims to expedite biomedical researches by generating novel hypotheses from existing scientific literature. Most existing studies focused on modeling static snapshots of the corpus, neglecting the temporal evolution of scien...
KGRACDA: A Model Based on Knowledge Graph from Recursion and Attention Aggregation for CircRNA-Disease Association Prediction.
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
CircRNA is closely related to human disease, so it is important to predict circRNA-disease association (CDA). However, the traditional biological detection methods have high difficulty and low accuracy, and computational methods represented by deep l...
An assessment of the influence of trade-off optimization in commercial knowledge based planning library creation for tongue cancer patients.
Medical dosimetry : official journal of the American Association of Medical Dosimetrists
Dec 6, 2024
This article aims to compare the dosimetric performance between knowledge-based plan (KBP) libraries with and without trade-off (TO) exploration using multicriterial optimization (MCO) for tongue cancer patients. The trade-off optimized library (KBP_...
Quality and mechanical efficiency of automated knowledge-based planning for volumetric-modulated arc therapy in head and neck cancer.
Journal of applied clinical medical physics
Dec 1, 2024
OBJECTIVES: This study aimed to examine the effectiveness of the automated RapidPlan in assessing plan quality and to explore how beam complexity affects the mechanical performance of volumetric modulated arc therapy for head and neck cancers.
Integrative analysis and knowledgebase construction of key candidate genes and pathways in age-related macular degeneration.
Experimental eye research
Nov 28, 2024
Age-related macular degeneration is a retinal disease that severely impacts vision in the older population. Its gene-related heterogeneity has not been fully studied, increasing the burden of precise treatment, prevention and prognosis. Genetic varia...
Interpretation knowledge extraction for genetic testing via question-answer model.
BMC genomics
Nov 9, 2024
BACKGROUND: Sequencing-based genetic testing is widely used in biomedical research, including pathogenic microorganism detection with metagenomic next-generation sequencing (mNGS). The application of sequencing results to clinical diagnosis and treat...
KnowVID-19: A Knowledge-Based System to Extract Targeted COVID-19 Information from Online Medical Repositories.
Biomolecules
Nov 6, 2024
We present KnowVID-19, a knowledge-based system that assists medical researchers and scientists in extracting targeted information quickly and efficiently from online medical literature repositories, such as PubMed, PubMed Central, and other biomedic...
Knowledge-based inductive bias and domain adaptation for cell type annotation.
Communications biology
Nov 5, 2024
Measurement techniques often result in domain gaps among batches of cellular data from a specific modality. The effectiveness of cross-batch annotation methods is influenced by inductive bias, which refers to a set of assumptions that describe the be...
An Accurate and Efficient Approach to Knowledge Extraction from Scientific Publications Using Structured Ontology Models, Graph Neural Networks, and Large Language Models.
International journal of molecular sciences
Nov 3, 2024
The rapid growth of biomedical literature makes it challenging for researchers to stay current. Integrating knowledge from various sources is crucial for studying complex biological systems. Traditional text-mining methods often have limited accuracy...
BioTRY: A Comprehensive Knowledge Base for Titer, Rate, and Yield of Biosynthesis.
ACS synthetic biology
Oct 18, 2024
Synthetic biology is rapidly evolving into a data-intensive science that increasingly relies on massive data sets; one of its applications is the evaluation of the economic viability of fermentation processes. However, the key economic indicators, na...
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